2026-08-29T12:56:22Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/171112024-09-21T20:05:25Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927

00925njm 22002777a 4500 dc García-Vilas, Javier A author Martínez-Poveda, Beatriz author Quesada, Ana R author Medina, Miguel Ángel author 2015-12-22 Organisms lacking external defense mechanisms have developed chemical defense strategies, particularly through the production of secondary metabolites with antibiotic or repellent effects. Secondary metabolites from marine organisms have proven to be an exceptionally rich source of small molecules with pharmacological activities potentially beneficial to human health. (+)-Aeroplysinin-1 is a secondary metabolite isolated from marine sponges with a wide spectrum of bio-activities. (+)-Aeroplysinin-1 has potent antibiotic effects on Gram-positive bacteria and several dinoflagellate microalgae causing toxic blooms. In preclinical studies, (+)-aeroplysinin-1 has been shown to have promising anti-inflammatory, anti-angiogenic and anti-tumor effects. Due to its versatility, (+)-aeroplysinin-1 might have a pharmaceutical interest for the treatment of different pathologies. 10.3390/md14010001 1660-3397 Marine drugs http://hdl.handle.net/10668/9679 26703630 http://hdl.handle.net/20.500.12105/17111 (+)-aeroplysinin-1 angiogenesis cancer inflammation marine drugs sponges Aeroplysinin-1, a Sponge-Derived Multi-Targeted Bioactive Marine Drug.