2026-08-05T11:42:17Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/170982024-11-28T14:44:48Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud
author
Fernández, Tahia D
author
Gómez, Enrique
author
Doña, Inmaculada
author
Campo, Paloma
author
Rondon, Carmen
author
Gonzalez, Miguel
author
Gomez, Francisca
author
Palomares, Francisca
author
Salas, Maria
author
Blanca, Miguel
author
Mayorga, Cristobalina
author
Torres, Maria J
authoraffiliation
[Fernández,TD; Gómez,E; Gonzalez,M; Palomares,F; Mayorga,C] Research Laboratory-Allergy Unit, IBIMA-Regional University Hospital of Malaga, UMA, Malaga, Spain. [Doña,I; Campo,P; Rondon,C; Gomez,F; Salas,M; Blanca,M; Mayorga,C; Torres,MJ] Allergy Service, IBIMA-Regional University Hospital of Malaga, UMA, Malaga, Spain.
2024-01-15T18:17:45Z
2024-01-15T18:17:45Z
2015-09-29
10.1038/srep14482
2045-2322
Scientific Reports
http://hdl.handle.net/10668/2287
26416023
http://hdl.handle.net/20.500.12105/17098
Allergic rhinitis is highly prevalent worldwide. Immunotherapy has been shown to control its symptoms, however, up to 30% of patients may not respond. Previous studies of the immunological mechanisms involved in allergen-immunotherapy (AIT) have focused on the humoral and T-cell response and several studies have evaluated some B-cell subpopulations during AIT and their role in immunological tolerance. However, although B and plasma-cell subpopulations are two of the most important cellular subtypes involved in allergic reactions, their relation with AIT efficacy remains unelucidated. The objective was to analyze the effects of immunotherapy on different B and plasma-cell subpopulations and whether these changes correlate with the clinical response to the treatment. Although no changes are found in B-cell subpopulations, responder patients show increased levels of memory B-cells even before the beginning of treatment. Changes in plasma-cell subpopulations are found, mainly in circulating inflammatory plasma-cells that could affect the response to the allergen. Moreover, an early increase of specific-IgG4 and IgG4 secreting-cells was found. All these suggest that the determination of the memory B-cells before the initiation of the treatment, and the quantification of IgG4 and IgG4-secreting-cells in the first months of immunotherapy, could serve as markers for the clinical response to treatment.
eng
Alérgenos
Linfocitos B
Desensibilización inmunológica
Inmunoglobulina G
Células plasmáticas
Rinitis alérgica
Linfocitos T
Differential Plasma-cell evolution is linked with Dermatophagoides pteronyssinus immunotherapy response.
research article