2026-08-05T11:42:12Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/170982024-11-28T14:44:48Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927

00925njm 22002777a 4500 dc Fernández, Tahia D author Gómez, Enrique author Doña, Inmaculada author Campo, Paloma author Rondon, Carmen author Gonzalez, Miguel author Gomez, Francisca author Palomares, Francisca author Salas, Maria author Blanca, Miguel author Mayorga, Cristobalina author Torres, Maria J author 2015-09-29 Allergic rhinitis is highly prevalent worldwide. Immunotherapy has been shown to control its symptoms, however, up to 30% of patients may not respond. Previous studies of the immunological mechanisms involved in allergen-immunotherapy (AIT) have focused on the humoral and T-cell response and several studies have evaluated some B-cell subpopulations during AIT and their role in immunological tolerance. However, although B and plasma-cell subpopulations are two of the most important cellular subtypes involved in allergic reactions, their relation with AIT efficacy remains unelucidated. The objective was to analyze the effects of immunotherapy on different B and plasma-cell subpopulations and whether these changes correlate with the clinical response to the treatment. Although no changes are found in B-cell subpopulations, responder patients show increased levels of memory B-cells even before the beginning of treatment. Changes in plasma-cell subpopulations are found, mainly in circulating inflammatory plasma-cells that could affect the response to the allergen. Moreover, an early increase of specific-IgG4 and IgG4 secreting-cells was found. All these suggest that the determination of the memory B-cells before the initiation of the treatment, and the quantification of IgG4 and IgG4-secreting-cells in the first months of immunotherapy, could serve as markers for the clinical response to treatment. 10.1038/srep14482 2045-2322 Scientific Reports http://hdl.handle.net/10668/2287 26416023 http://hdl.handle.net/20.500.12105/17098 Alérgenos Linfocitos B Desensibilización inmunológica Inmunoglobulina G Células plasmáticas Rinitis alérgica Linfocitos T Differential Plasma-cell evolution is linked with Dermatophagoides pteronyssinus immunotherapy response.