2026-04-29T00:59:44Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/170962024-11-28T15:50:21Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16984
Repisalud
author
Mansego, Maria L
author
De Marco, Griselda
author
Ivorra, Carmen
author
Lopez-Izquierdo, Raúl
author
Morcillo, Sonsoles
author
Rojo-Martínez, Gemma
author
González-Albert, Verónica
author
Martínez, Fernando
author
Soriguer, Federico
author
Martín-Escudero, Juan C
author
Redon, Josep
author
Chaves, F Javier
authoraffiliation
[Mansego,ML; De Marco,G; Ivorra,C; Martínez,F; Redon,J] CIBER Physiopathology of Obesity and Nutrition CIBERobn, CB06/03, Institute of Health Carlos III , Madrid, Spain. [Mansego,ML; De Marco,G; González-Albert,V; Chaves,FJ] Genotyping and Genetic Diagnosis Unit, Fundación de Investigación del Hospital Clínico de Valencia-INCLIVA, Valencia, Spain. [De Marco,G, Morcillo,S; Rojo-Martínez,G; Soriguer,F, Chaves,FJ] CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, Spain. [Iborra,C] Cardiovascular Risk Unit, Consorcio, Hospital General, University of Valencia, Valencia, Spain. [Lopez-Izquierdo,R; Martín-Escudero,JC] Internal Medicine Unit, Rio Hortega Hospital, Valladolid, Spain. [Morcillo,S; Rojo-Martínez,G; Soriguer,F] Endocrinology and Nutrition Department, Carlos Haya University Hospital and Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain. [Martinez,F; Rendon,J] Hypertension Clinic, Hospital Clínico Universitario de Valencia, Valencia, Spain.
2024-01-15T18:17:42Z
2024-01-15T18:17:42Z
2015-09-02
http://hdl.handle.net/10668/2326
http://hdl.handle.net/20.500.12105/17096
26329592
10.1186/s12967-015-0652-4
1479-5876
Journal of translational medicine
BACKGROUND: Abdominal obesity (AO) is a common modifiable risk factor for certain non-communicable diseases associated with enhanced oxidative stress (OS). The objective of this work was to investigate whether the interaction between antioxidant vitamin intake and OS-related polymorphisms modulates gene-associated anthropometry in a Spanish population. METHODS: A total of 246 subjects with AO, and 492 age and gender matched non-AO subjects were included in the study. Anthropometric, biochemical, and OS parameters, and antioxidant dietary intake data were assessed using validated procedures. DNA from white blood cells was isolated and the genotype of seven polymorphisms from genes involved in OS (pro-oxidant and antioxidant) were analyzed using the SNPlex system. The effects of the c.-793T > C polymorphism on promoter activity and thus thioredoxin (TXN) activity were examined using reporter assays. RESULTS: The AO group had higher 8-Oxo-2'-deoxyguanosine levels and took in less vitamin A and vitamin E compared to the non-AO group. Logistic regression analysis revealed that the rs2301241 polymorphism in TXN and rs740603 in catechol-O-methyltransferase (COMT) were associated with waist circumference (WC) and AO. Moreover, these polymorphisms were more strongly associated with variations in WC in subjects with low vitamin E intakes. A promoter assay revealed that the T to C conversion at c.-793 (rs2301241) induced a more than two fold increase in reporter gene expression. CONCLUSIONS: WC is associated both with dietary vitamin E intake and genetic variants of TXN and COMT suggesting that existence of a complex nutrigenetic pathway that involves regulation of AO.
eng
Vitamin E intake
Oxidative stress
Polimorphism
Waist circumference
Abdominal obesity
Thioredoxin
Catechol-O-methyltransferase
Antioxidantes
Dieta
Genes informadores
Genotipo
Nutrigenómica
Obesidad abdominal
Factores de riesgo
Vitamina E
Perímetro abdominal
The nutrigenetic influence of the interaction between dietary vitamin E and TXN and COMT gene polymorphisms on waist circumference: a case control study.
research article