2026-06-14T03:37:46Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/170842024-11-28T14:43:06Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16984
Repisalud
author
Martínez-Barquero, Vanesa
author
de Marco, Griselda
author
Martínez-Hervas, Sergio
author
Rentero, Pilar
author
Galan-Chilet, Inmaculada
author
Blesa, Sebastian
author
Morchon, David
author
Morcillo, Sonsoles
author
Rojo, Gemma
author
Ascaso, Juan Francisco
author
Real, José Tomás
author
Martín-Escudero, Juan Carlos
author
Chaves, Felipe Javier
authoraffiliation
[Martínez-Barquero,V; Martínez-Hervas,S; Ascaso,JF; Real,JT] Department of Medicine, University of Valencia, Valencia, Spain. [Martínez-Barquero,V; de Marco,G; Rentero,P; Galan-Chilet,I; Blesa,S; Chaves,FJ] Genotyping and Genetic Diagnosis Unit, Hospital Clínico Research Foundation (INCLIVA), Valencia, Spain. [Martínez-Hervas,S; Morcillo,S; Rojo,G; Ascaso,JF; Real,JT; Chaves,FJ] CIBER of Diabetes and Associated Metabolic Diseases (CIBERDEM), Barcelona, Spain. [Morcillo,S; Rojo G] Service of Endocrinology and Nutrition, Hospital Regional Universitario, Málaga, Spain, Instituto de Biomedicina de Málaga (IBIMA), Málaga, Spain. [Martínez-Hervas,S; Ascaso,JF; Real, JT] Service of Endocrinology and Nutrition, Hospital Clínico Universitario de Valencia, Valencia, Spain. [Morchon,D; Martín-Escudero,JC] Internal Medicine, Rio Hortega Hospital, University of Valladolid, Valladolid, Spain.
2024-01-15T18:17:31Z
2024-01-15T18:17:31Z
2015-03-23
10.1371/journal.pone.0118471
1932-6203
PloS One
http://hdl.handle.net/10668/2324
25799405
http://hdl.handle.net/20.500.12105/17084
BACKGROUND/OBJECTIVES: Obesity has been linked to morbidity and mortality through increased risk for many chronic diseases. Endothelin (EDN) system has been related to endothelial function but it can be involved in lipid metabolism regulation: Receptor type A (EDNRA) activates lipolysis in adipocytes, the two endothelin receptors mediate arsenic-stimulated adipocyte dysfunction, and endothelin system can regulate adiposity by modulating adiponectin activity in different situations and, therefore, influence obesity development. The aim of the present study was to analyze if single nucleotide polymorphisms (SNPs) in the EDN system could be associated with human obesity. SUBJECTS/METHODS: We analyzed two samples of general-population-based studies from two different regions of Spain: the VALCAR Study, 468 subjects from the area of Valencia, and the Hortega Study, 1502 subjects from the area of Valladolid. Eighteen SNPs throughout five genes were analyzed using SNPlex. RESULTS: We found associations for two polymorphisms of the EDNRB gene which codifies for EDN receptor type B. Genotypes AG and AA of the rs5351 were associated with a lower risk for obesity in the VALCAR sample (p=0.048, OR=0.63) and in the Hortega sample (p=0.001, OR=0.62). Moreover, in the rs3759475 polymorphism, genotypes CT and TT were also associated with lower risk for obesity in the Hortega sample (p=0.0037, OR=0.66) and in the VALCAR sample we found the same tendency (p=0.12, OR=0.70). Furthermore, upon studying the pooled population, we found a stronger association with obesity (p=0.0001, OR=0.61 and p=0.0008, OR=0.66 for rs5351 and rs3759475, respectively). Regarding plasma arsenic levels, we have found a positive association for the two SNPs studied with obesity risk in individuals with higher arsenic levels in plasma: rs5351 (p=0.0054, OR=0.51) and rs3759475 (p=0.009, OR=0.53). CONCLUSIONS: Our results support the hypothesis that polymorphisms of the EDNRB gene may influence the susceptibility to obesity and can interact with plasma arsenic levels.
eng
Adipocitos
Arsénico
Enfermedad crónica
Genotipo
Obesidad
Polimorfismo de nucleótido único
Receptores de endotelinas
España
Tomografía computarizada por rayos X
Polymorphisms in endothelin system genes, arsenic levels and obesity risk.
research article