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Repisalud author Rojo-Martínez, Gemma author Maymó-Masip, Elsa author Rodríguez, M Mar author Solano, Esther author Goday, Albert author Soriguer, Federico author Valdés, Sergio author Chaves, Felipe Javier author Delgado, Elías author Colomo, Natalia author Hernández, Pilar author Vendrell, Joan author Chacón, Matilde R authoraffiliation [Rojo-Martínez,G; Soriguer,F; Valdés,S; Colomo,N] UGCI de Endocrinología y Nutrición, Instituto de Biomedicina de Málaga (IBIMA), Hospital Regional Universitario, Málaga, Spain. [Rojo-Martínez,G; Maymó-Masip,E; Solano,E; Soriguer,F; Valdés,S; Chaves,FJ; Colomo,N; Vendrell,J; Chacón,MR] Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas CIBERDEM, Barcelona, Spain. Maymó-Masip,E; Solano,E; Hernández,P; Vendrel,J; Chacón,MR] Hospital Universitari de Tarragona Joan XXIII, IISPV, Universitat Rovira i Virgili, Tarragona, Spain. [Rodríguez,MM] CIBERObn Fisiopatología, Obesidad y Nutrición, Institut D’investigacio Biomedica De Girona Dr Josep Trueta, Girona, Spain. [Goday,A] Department of Endocrinology and Nutrition Hospital del Mar, Parc de Salut Mar, Universitat Autónoma de Barcelona, Barcelona, Spain. [Chaves,FJ] Genotyping and Genetic Diagnosis Unit, Fundación de Investigación del Hospital Clínico de Valencia-INCLIVA, Valencia, Spain. [Delgado,E] Departamento de Medicina-Endocrinología y Nutrición, Hospital Universitario Central de Asturias (HUCA), Universidad de Oviedo, Oviedo, Spain. 2024-01-15T18:17:18Z 2024-01-15T18:17:18Z 2014-06-30 10.1371/journal.pone.0101250 1932-6203 PloS ONE http://hdl.handle.net/10668/1990 24978196 http://hdl.handle.net/20.500.12105/17071 OBJECTIVE: Serum levels of soluble TNF-like weak inducer of apoptosis (sTWEAK) and its scavenger receptor CD163 (sCD163) have been linked to insulin resistance. We analysed the usefulness of these cytokines as biomarkers of type 2 diabetes in a Spanish cohort, together with their relationship to food consumption in the setting of the Di@bet.es study. RESEARCH DESIGN AND METHODS: This is a cross-sectional, matched case-control study of 514 type 2 diabetes subjects and 517 controls with a Normal Oral Glucose Tolerance Test (NOGTT), using data from the Di@bet.es study. Study variables included clinical and demographic structured survey, food frequency questionnaire and physical examination. Serum concentrations of sTWEAK and sCD163 were measured by ELISA. Linear regression analysis determined which variables were related to sTWEAK and sCD163 levels. Logistic regression analysis was used to estimate odd ratios of presenting type 2 diabetes. RESULTS: sCD163 concentrations and sCD163/sTWEAK ratio were 11.0% and 15.0% higher, respectively, (P<0.001) in type 2 diabetes than in controls. Following adjustment for various confounders, the OR for presenting type 2 diabetes in subjects in the highest vs the lowest tertile of sCD163 was [(OR), 2,01 (95%CI, 1,46-2,97); P for trend <0.001]. Coffee and red wine consumption was negatively associated with serum levels of sCD163 (P = 0.0001 and; P = 0.002 for coffee and red wine intake, respectively). CONCLUSIONS: High circulating levels of sCD163 are associated with type 2 diabetes in the Spanish population. The association between coffee and red wine intake and these biomarkers deserves further study to confirm its potential role in type 2 diabetes. eng Café Diabetes mellitus tipo II Conducta bebedora Hábitos alimenticios Funciones de verosimilitud Solubilidad Vino España Serum sCD163 levels are associated with type 2 diabetes mellitus and are influenced by coffee and wine consumption: results of the Di@bet.es study. research article