2026-05-22T04:08:02Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/170552024-11-28T14:42:53Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud
author
Castilla-Ortega, Estela
author
Escuredo, Leticia
author
Bilbao, Ainhoa
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Pedraza, Carmen
author
Orio, Laura
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Estivill-Torrús, Guillermo
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Santín, Luis J
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Rodríguez de Fonseca, Fernando
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Pavón, Francisco Javier
authoraffiliation
[Castilla-Ortega,E; Bilbao,A; Orio,L; Rodríguez de Fonseca,F; Pavón,FJ] Unidad de Gestión Clínica de Salud Mental, Hospital Regional Universitario de Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain. [Castilla-Ortega,E; Pedraza,C; Santín, LJ] Departamento de Psicobiología y Metodología de las Ciencias del Comportamiento, Universidad de Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain. [Escuredo,L; Orio,L; Rodríguez de Fonseca,F] Departamento de Psicobiología, Universidad Complutense de Madrid, Madrid, Spain. [Estivill-Torrús,G] Unidad de Gestión Clínica de Neurociencias, Hospital Regional Universitario de Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain.
2024-01-15T18:17:04Z
2024-01-15T18:17:04Z
2014-01-07
10.1371/journal.pone.0085348
1932-6203
PloS one
http://hdl.handle.net/10668/1611
24409327
http://hdl.handle.net/20.500.12105/17055
The role of lysophosphatidic acid (LPA) in the control of emotional behavior remains to be determined. We analyzed the effects of the central administration of 1-oleoyl-LPA (LPA 18∶1) in rats tested for food consumption and anxiety-like and depression-like behaviors. For this purpose, the elevated plus-maze, open field, Y maze, forced swimming and food intake tests were performed. In addition, c-Fos expression in the dorsal periaqueductal gray matter (DPAG) was also determined. The results revealed that the administration of LPA 18∶1 reduced the time in the open arms of the elevated plus-maze and induced hypolocomotion in the open field, suggesting an anxiogenic-like phenotype. Interestingly, these effects were present following LPA 18∶1 infusion under conditions of novelty but not under habituation conditions. In the forced swimming test, the administration of LPA 18∶1 dose-dependently increased depression-like behavior, as evaluated according to immobility time. LPA treatment induced no effects on feeding. However, the immunohistochemical analysis revealed that LPA 18∶1 increased c-Fos expression in the DPAG. The abundant expression of the LPA1 receptor, one of the main targets for LPA 18∶1, was detected in this brain area, which participates in the control of emotional behavior, using immunocytochemistry. These findings indicate that LPA is a relevant transmitter potentially involved in normal and pathological emotional responses, including anxiety and depression.
eng
receptores de ácidos lisofosfatídicos
Conducta animal
Depresión
Ratas
Ansiedad
Evaluación nutricional
Aprendizaje por laberinto
Natación
Inmunohistoquímica
Oleoyl lysophosphatidic acid: a new mediator of emotional behavior in rats.
research article