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oai:repisalud.isciii.es:20.500.12105/170552024-11-28T14:42:53Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927

00925njm 22002777a 4500 dc Castilla-Ortega, Estela author Escuredo, Leticia author Bilbao, Ainhoa author Pedraza, Carmen author Orio, Laura author Estivill-Torrús, Guillermo author Santín, Luis J author Rodríguez de Fonseca, Fernando author Pavón, Francisco Javier author 2014-01-07 The role of lysophosphatidic acid (LPA) in the control of emotional behavior remains to be determined. We analyzed the effects of the central administration of 1-oleoyl-LPA (LPA 18∶1) in rats tested for food consumption and anxiety-like and depression-like behaviors. For this purpose, the elevated plus-maze, open field, Y maze, forced swimming and food intake tests were performed. In addition, c-Fos expression in the dorsal periaqueductal gray matter (DPAG) was also determined. The results revealed that the administration of LPA 18∶1 reduced the time in the open arms of the elevated plus-maze and induced hypolocomotion in the open field, suggesting an anxiogenic-like phenotype. Interestingly, these effects were present following LPA 18∶1 infusion under conditions of novelty but not under habituation conditions. In the forced swimming test, the administration of LPA 18∶1 dose-dependently increased depression-like behavior, as evaluated according to immobility time. LPA treatment induced no effects on feeding. However, the immunohistochemical analysis revealed that LPA 18∶1 increased c-Fos expression in the DPAG. The abundant expression of the LPA1 receptor, one of the main targets for LPA 18∶1, was detected in this brain area, which participates in the control of emotional behavior, using immunocytochemistry. These findings indicate that LPA is a relevant transmitter potentially involved in normal and pathological emotional responses, including anxiety and depression. 10.1371/journal.pone.0085348 1932-6203 PloS one http://hdl.handle.net/10668/1611 24409327 http://hdl.handle.net/20.500.12105/17055 receptores de ácidos lisofosfatídicos Conducta animal Depresión Ratas Ansiedad Evaluación nutricional Aprendizaje por laberinto Natación Inmunohistoquímica Oleoyl lysophosphatidic acid: a new mediator of emotional behavior in rats.