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oai:repisalud.isciii.es:20.500.12105/170452024-09-21T23:48:57Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud author Rodriguez-Pacheco, F author Novelle, M G author Vazquez, M J author Garcia-Escobar, E author Soriguer, F author Rojo-Martinez, G author García-Fuentes, E author Malagon, M M author Dieguez, C authoraffiliation [Rodriguez-Pacheco,F; Novelle,MG; Vazquez,MJ; Dieguez,C] Department of Physiology, School of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain. [Rodriguez-Pacheco,F; Novelle,MG; Vazquez, MJ; Malagon,MM; Dieguez,C] CIBER FisiopatologÍa de la Obesidad y Nutrición (CIBERobn), Spain. [Rodriguez-Pacheco,F; Garcia-Escobar,E; Soriguer,F; Romo-Martinez,G; García-Fuentes,E] Endocrinology and Nutrition Service, Carlos Haya Hospital, Fundación IMABIS, MÁlaga, Spain. [Garcia-Escobar,E; Soriguer,F; Rojo-Martinez,G; García-Fuentes,E] CIBER Diabetes and Metabolic Illness (CIBER-DEM), Spain. [Malagon,MM] Department of Cellular Biology, Physiology and Inmunology, School of Siences, University of CÓrdoba, Córdoba, Spain. 2024-01-15T18:16:56Z 2024-01-15T18:16:56Z 2013 10.1155/2013/479739 1466-1861 0962-9351 Mediators of inflammation http://hdl.handle.net/10668/1440 23710116 http://hdl.handle.net/20.500.12105/17045 The adipokine resistin is an insulin-antagonizing factor that also plays a regulatory role in inflammation, immunity, food intake, and gonadal function and also regulates growth hormone (GH) secretion in rat adenopituitary cells cultures with the adipokine. Although adipose tissue is the primary source of resistin, it is also expressed in other tissues, including the pituitary. The aim of this study is to investigate the possible action of resistin on the lipid metabolism in the pituitary gland in vivo (rats in two different nutritional status, fed and fast, treated with resistin on acute and a chronic way) and in vitro (adenopituitary cell cultures treated with the adipokine). Here, by a combination of in vivo and in vitro experimental models, we demonstrated that central acute and chronic administration of resistin enhance mRNA levels of the lipid metabolic enzymes which participated on lipolysis and moreover inhibiting mRNA levels of the lipid metabolic enzymes involved in lipogenesis. Taken together, our results demonstrate for the first time that resistin has a regulatory role on lipid metabolism in the pituitary gland providing a novel insight in relation to the mechanism by which this adipokine can participate in the integrated control of lipid metabolism. eng Resistina Antagonistas de la insulina Inflamación Inmunidad Ingestión de Alimentos Gónadas Hormona del crecimiento Ratas Hipófisis Lipogénesis Resistin regulates pituitary lipid metabolism and inflammation in vivo and in vitro. research article