2026-06-14T03:40:35Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/170442024-11-28T14:43:02Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16961col_20.500.12105_16980
Repisalud
author
Palacín, Arantxa
author
Gómez-Casado, Cristina
author
Rivas, Luis A
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Aguirre, Jacobo
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Tordesillas, Leticia
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Bartra, Joan
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Carrillo, Teresa
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Cuesta-Herranz, Javier
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Frutos, Consolación de
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García Alvarez-Eire, Genoveva
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Fernández, Francisco J
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Gamboa, Pedro
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Muñoz, Rosa
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Sánchez-Monge, Rosa
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Sirvent, Sofía
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Torres, María J
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Varela-Losada, Susana
author
Rodríguez, Rosalía
author
Parro, Victor
author
Blanca, Miguel
author
Salcedo, Gabriel
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Díaz-Perales, Araceli
authoraffiliation
[Palacín,A; Gómez-Casado,C; Tordesillas,L; Sánchez-Monge,R; Díaz-Perales,A] Centro de Biotecnología y Genómica de Plantas (UPM-INIA), Pozuelo de Alarcón, Madrid, Spain. [Rivas,LA; Aguirre,J; Parro,V] Departamento de Evolución Molecular, Centro de Astrobiología (INTA-CSIC), Torrejón de Ardoz, Madrid, Spain. [Bartra,J; Muñoz,R] Unitat d’Alèrgia Servei Pneumologia i Alèrgia Respiratòria Universitat de Barcelona, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigaciones Biomédicas en Red de Enfermedades Respiratorias (CIBERES), Barcelona, Spain. [Blanco,C; Frutos,C de] Servicio de Alergia, Hospital Universitario de la Princesa, Instituto de Investigación Sanitaria Princesa (IP), Madrid, Spain. [Carrillo,T] Servicio de Alergología, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain. [Cuesta-Herranz,J] Unidad Servicio de Alergia, Fundación Jiménez Díaz, Madrid, Spain. [Fernández,FJ] Allergy Section, General University Hospital, Miguel Hernández University, Elche, Spain. [García Álvarez-Eire,G; Varela-Losada,S] Unidad de Alergología, Complexo Hospitalario, Ourense, Spain. [Torres,MJ; Blanca,M] Research Laboratory, Fundación IMABIS-Carlos Haya Hospital; Hospital Civil, Málaga, Spain. [Gamboa,P] Servicio de Alergia, Hospital de Basurto, Bilbao, Spain. [Sirvent,S; Rodríguez,R] Departamento de Bioquímica y Biología Molecular I, Facultad de Químicas, Universidad Complutense, Madrid, Spain. [Salcedo,G] Departamento de Biotecnología, ETSI Agrónomos, Universidad Politécnica, Madrid, Spain.
2024-01-15T18:16:55Z
2024-01-15T18:16:55Z
2012-12-14
10.1371/journal.pone.0050799
1932-6203
PloS one
http://hdl.handle.net/10668/1212
23272072
http://hdl.handle.net/20.500.12105/17044
The study of cross-reactivity in allergy is key to both understanding. the allergic response of many patients and providing them with a rational treatment In the present study, protein microarrays and a co-sensitization graph approach were used in conjunction with an allergen microarray immunoassay. This enabled us to include a wide number of proteins and a large number of patients, and to study sensitization profiles among members of the LTP family. Fourteen LTPs from the most frequent plant food-induced allergies in the geographical area studied were printed into a microarray specifically designed for this research. 212 patients with fruit allergy and 117 food-tolerant pollen allergic subjects were recruited from seven regions of Spain with different pollen profiles, and their sera were tested with allergen microarray. This approach has proven itself to be a good tool to study cross-reactivity between members of LTP family, and could become a useful strategy to analyze other families of allergens.
eng
Reacciones Cruzadas
Estudios multicéntricos como asunto
Hipersensibilidad
Análisis de micromatrices
Inmunoanálisis
España
Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study.
research article