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00925njm 22002777a 4500 dc Palacín, Arantxa author Gómez-Casado, Cristina author Rivas, Luis A author Aguirre, Jacobo author Tordesillas, Leticia author Bartra, Joan author Carrillo, Teresa author Cuesta-Herranz, Javier author Frutos, Consolación de author García Alvarez-Eire, Genoveva author Fernández, Francisco J author Gamboa, Pedro author Muñoz, Rosa author Sánchez-Monge, Rosa author Sirvent, Sofía author Torres, María J author Varela-Losada, Susana author Rodríguez, Rosalía author Parro, Victor author Blanca, Miguel author Salcedo, Gabriel author Díaz-Perales, Araceli author 2012-12-14 The study of cross-reactivity in allergy is key to both understanding. the allergic response of many patients and providing them with a rational treatment In the present study, protein microarrays and a co-sensitization graph approach were used in conjunction with an allergen microarray immunoassay. This enabled us to include a wide number of proteins and a large number of patients, and to study sensitization profiles among members of the LTP family. Fourteen LTPs from the most frequent plant food-induced allergies in the geographical area studied were printed into a microarray specifically designed for this research. 212 patients with fruit allergy and 117 food-tolerant pollen allergic subjects were recruited from seven regions of Spain with different pollen profiles, and their sera were tested with allergen microarray. This approach has proven itself to be a good tool to study cross-reactivity between members of LTP family, and could become a useful strategy to analyze other families of allergens. 10.1371/journal.pone.0050799 1932-6203 PloS one http://hdl.handle.net/10668/1212 23272072 http://hdl.handle.net/20.500.12105/17044 Reacciones Cruzadas Estudios multicéntricos como asunto Hipersensibilidad Análisis de micromatrices Inmunoanálisis España Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study.