2026-08-29T10:37:53Zhttps://repisalud.isciii.es/rest/oai/request
oai:repisalud.isciii.es:20.500.12105/170382024-11-28T15:07:56Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud author Garrido-Sánchez, Lourdes author García-Fuentes, Eduardo author Fernández-García, Diego author Escoté, Xavier author Alcaide, Juan author Pérez-Martínez, Pablo author Vendrell, Joan author Tinahones, Francisco J authoraffiliation [Garrido-Sánchez,L; Escoté,X; Vendrell,J] CIBERDEM, Hospital Universitari Joan XXIII, Pere Virgili Institute, Tarragona, Spain. [García-Fuentes,E; AlcaideJ] Fundación IMABIS, Málaga, Spain. [García-Fuentes,E; Fernández-García,D; Pérez-Martínez,P] Ciber Fisiopatología Obesidad y Nutrición (CIBEROBN), Málaga, Spain. [Alcaide,J; Tinahones,FJ] Servicio de Endocrinología y Nutrición, Hospital Universitario Virgen de la Victoria, Málaga, Spain. [Pérez-Martínez,P] Servicio de Medicina Interna, Hospital Universitario Reina Sofía, Córdoba, Spain. 2024-01-15T18:16:48Z 2024-01-15T18:16:48Z 2012-03-19 10.1371/journal.pone.0033264 1932-6203 PloS one http://hdl.handle.net/10668/1158 22442679 http://hdl.handle.net/20.500.12105/17038 OBJECTIVE: Zinc-α(2) glycoprotein (ZAG) stimulates lipid loss by adipocytes and may be involved in the regulation of adipose tissue metabolism. However, to date no studies have been made in the most extreme of obesity. The aims of this study are to analyze ZAG expression levels in adipose tissue from morbidly obese patients, and their relationship with lipogenic and lipolytic genes and with insulin resistance (IR). METHODS: mRNA expression levels of PPARγ, IRS-1, IRS-2, lipogenic and lipolytic genes and ZAG were quantified in visceral (VAT) and subcutaneous adipose tissue (SAT) of 25 nondiabetic morbidly obese patients, 11 with low IR and 14 with high IR. Plasma ZAG was also analyzed. RESULTS: The morbidly obese patients with low IR had a higher VAT ZAG expression as compared with the patients with high IR (p = 0.023). In the patients with low IR, the VAT ZAG expression was greater than that in SAT (p = 0.009). ZAG expression correlated between SAT and VAT (r = 0.709, p<0.001). VAT ZAG expression was mainly predicted by insulin, HOMA-IR, plasma adiponectin and expression of adiponectin and ACSS2. SAT ZAG expression was only predicted by expression of ATGL. CONCLUSIONS: ZAG could be involved in modulating lipid metabolism in adipose tissue and is associated with insulin resistance. These findings suggest that ZAG may be a useful target in obesity and related disorders, such as diabetes. eng IRS1 protein, human Zn-alpha-2-glycoprotein marneral synthase, Arabidopsis Proteínas de Arabidopsis Regulación de la Expresión Génica Proteínas Sustrato del Receptor de Insulina Resistencia a la Insulina Grasa Intraabdominal Transferasas Intramoleculares Lipólisis Obesidad Mórbida Proteínas de Plasma Seminal Grasa Subcutánea Zinc-alpha 2-glycoprotein gene expression in adipose tissue is related with insulin resistance and lipolytic genes in morbidly obese patients. research article