2026-04-28T21:35:23Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/170362024-11-28T15:27:30Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927
Repisalud
author
Garrido-Sánchez, Lourdes
author
Vendrell, Joan
author
Fernández-García, Diego
author
Ceperuelo-Mallafré, María Victoria
author
Chacón, Matilde R
author
Ocaña-Wilhelmi, Luis
author
Alcaide, Juan
author
Tinahones Madueño, Francisco José
author
García-Fuentes, Eduardo
authoraffiliation
[Garrido-Sánchez,L; Vendrell,J; Chacón,MR] Hospital Universitari Joan XXIII, IISPV, Tarragona, Spain. [Fernández-García,D; Ceperuelo-Mallafré,MV; Tinahones Madueño,FJ] Servicio de Endocrinología y Nutrición, Hospital Universitario Virgen de la Victoria, Málaga, Spain. [Ocaña-Wilhelmi,L] Servicio de Cirugía, Hospital Universitario Virgen de la Victoria, Málaga, Spain. [Alcaide,J; García-Fuentes,E] Fundación IMABIS, Málaga, Spain.
2024-01-15T18:16:46Z
2024-01-15T18:16:46Z
2012-02-23
http://hdl.handle.net/10668/658
http://hdl.handle.net/20.500.12105/17036
22384010
10.1371/journal.pone.0031280
1932-6203
PloS One
OBJECTIVE: De novo lipogenesis is involved in fatty acid biosynthesis and could be involved in the regulation of the triglyceride storage capacity of adipose tissue. However, the association between lipogenic and lipolytic genes and the evolution of morbidly obese subjects after bariatric surgery remains unknown. In this prospective study we analyze the association between the improvement in the morbidly obese patients as a result of bariatric surgery and the basal expression of lipogenic and lipolytic genes. METHODS: We study 23 non diabetic morbidly obese patients who were studied before and 7 months after bariatric surgery. Also, we analyze the relative basal mRNA expression levels of lipogenic and lipolytic genes in epiploic visceral adipose tissue (VAT) and abdominal subcutaneous adipose tissue (SAT). RESULTS: When the basal acetyl-CoA carboxylase 1 (ACC1), acetyl-CoA synthetase 2 (ACSS2) and ATP citrate lyase (ACL) expression in SAT was below percentile-50, there was a greater decrease in weight (P = 0.006, P = 0.034, P = 0.026), body mass index (P = 0.008, P = 0.033, P = 0.034) and hip circumference (P = 0.033, P = 0.021, P = 0.083) after bariatric surgery. In VAT, when the basal ACSS2 expression was below percentile-50, there was a greater decrease in hip circumference (P = 0.006). After adjusting for confounding variables in logistic regression models, only the morbidly obese patients with SAT or VAT ACSS2 expression ≥ P50 before bariatric surgery had a lower percentage hip circumference loss (<P50) after bariatric surgery (SAT: P = 0.039; VAT: P = 0.033). CONCLUSIONS: A lower basal ACSS2, ACC1 and ACL expression, genes involved in de novo lipogenesis, is associated with a better evolution of anthropometric variables after bariatric surgery. Thus, the previous state of the pathways involved in fatty acid metabolism may have repercussions on the improvement of these patients.
eng
aminoglycoside N1-acetyltransferase
ACACB protein, human
Acetil CoA Carboxilasa
Acetiltransferasas
Tejido adiposo
Antropometría
Cirugía bariátrica
Grasa Intraabdominal
Lipogénesis
lipolisis
ARN Mensajero
Grasa subcutánea
ATP Citrato (pro-S)-Liasa
De novo lipogenesis in adipose tissue is associated with course of morbid obesity after bariatric surgery.
research article