2026-04-29T00:59:39Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/170282025-05-05T09:57:43Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16969
Repisalud
author
López Gómez, Carlos
author
Fernández, Oscar
author
García León, Juan Antonio
author
Pinto-Medel, María Jesús
author
Oliver Martos, Begoña
author
Ortega-Pinazo, Jesús
author
Suardíaz, Margarita
author
García Trujillo, Lucía
author
Guijarro Castro, Cristina
author
Benito León, Julián
author
Prat, Isidro
author
Varadé, Jezabel
author
Álvarez-Lafuente, Roberto
author
Urcelay, Elena
author
Leyva, Laura
authoraffiliation
[López,C; García,JA; Pinto,MJ; Oliver,B; Ortega,J; Suardíaz,M; Leyva,L] Research Laboratory, Clinical Neurosciences Institute, Hospital Universitario Carlos Haya and Fundación IMABIS, Málaga, Spain. [Fernández,O] Departament of Neurology, Clinical Neurosciences Institute, Hospital Regional Universitario Carlos Haya and Fundación IMABIS, Málaga, Spain. [Guijarro,C; Benito,J] Departament of Neurology, University Hospital 12 de Octubre, Madrid, Spain. [Benito,J] Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Madrid. Spain. Department of Medicine, Complutense University, Madrid, Spain. [Prat,I] Transfusion Center Blood Bank, Málaga, Spain. [Varadé,J; Urcelay,E] Department of Immunology, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain. [Álvarez,R] Department of Neurology, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain.
2024-01-15T18:16:38Z
2024-01-15T18:16:38Z
2011-07-21
http://hdl.handle.net/10668/489
http://hdl.handle.net/20.500.12105/17028
21814551
10.1371/journal.pone.0021766
1932-6203
PLoS ONE
The TNF-related apoptosis inducing ligand (TRAIL)/TRAIL receptor system participates in crucial steps in immune cell activation or differentiation. It is able to inhibit proliferation and activation of T cells and to induce apoptosis of neurons and oligodendrocytes, and seems to be implicated in autoimmune diseases. Thus, TRAIL and TRAIL receptor genes are potential candidates for involvement in susceptibility to multiple sclerosis (MS). To test whether single-nucleotide polymorphisms (SNPs) in the human genes encoding TRAIL, TRAILR-1, TRAILR-2, TRAILR-3 and TRAILR-4 are associated with MS susceptibility, we performed a candidate gene case-control study in the Spanish population. 59 SNPs in the TRAIL and TRAIL receptor genes were analysed in 628 MS patients and 660 controls, and validated in an additional cohort of 295 MS patients and 233 controls. Despite none of the SNPs withstood the highly conservative Bonferroni correction, three SNPs showing uncorrected p values<0.05 were successfully replicated: rs4894559 in TRAIL gene, p = 9.8×10(-4), OR = 1.34; rs4872077, in TRAILR-1 gene, p = 0.005, OR = 1.72; and rs1001793 in TRAILR-2 gene, p = 0.012, OR = 0.84. The combination of the alleles G/T/A in these SNPs appears to be associated with a reduced risk of developing MS (p = 2.12×10(-5), OR = 0.59). These results suggest that genes of the TRAIL/TRAIL receptor system exerts a genetic influence on MS.
eng
Adolescente
Adulto
Anciano
Estudios de Casos y Controles
Estudios de Cohortes
Susceptibilidad a Enfermedades
Femenino
Genotipo
Humanos
Masculino
Mediana Edad
Multiple Esclerosis
Polimorfismo de Nucleótido Simple
Receptores del Ligando Inductor de Apoptosis Relacionado con TNF
Ligando Inductor de Apoptosis Relacionado con TNF
España
Adulto Joven
TRAIL/TRAIL Receptor System and Susceptibility to Multiple Sclerosis
research article