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oai:repisalud.isciii.es:20.500.12105/170282025-05-05T09:57:43Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927col_20.500.12105_16969

00925njm 22002777a 4500 dc López Gómez, Carlos author Fernández, Oscar author García León, Juan Antonio author Pinto-Medel, María Jesús author Oliver Martos, Begoña author Ortega-Pinazo, Jesús author Suardíaz, Margarita author García Trujillo, Lucía author Guijarro Castro, Cristina author Benito León, Julián author Prat, Isidro author Varadé, Jezabel author Álvarez-Lafuente, Roberto author Urcelay, Elena author Leyva, Laura author 2011-07-21 The TNF-related apoptosis inducing ligand (TRAIL)/TRAIL receptor system participates in crucial steps in immune cell activation or differentiation. It is able to inhibit proliferation and activation of T cells and to induce apoptosis of neurons and oligodendrocytes, and seems to be implicated in autoimmune diseases. Thus, TRAIL and TRAIL receptor genes are potential candidates for involvement in susceptibility to multiple sclerosis (MS). To test whether single-nucleotide polymorphisms (SNPs) in the human genes encoding TRAIL, TRAILR-1, TRAILR-2, TRAILR-3 and TRAILR-4 are associated with MS susceptibility, we performed a candidate gene case-control study in the Spanish population. 59 SNPs in the TRAIL and TRAIL receptor genes were analysed in 628 MS patients and 660 controls, and validated in an additional cohort of 295 MS patients and 233 controls. Despite none of the SNPs withstood the highly conservative Bonferroni correction, three SNPs showing uncorrected p values<0.05 were successfully replicated: rs4894559 in TRAIL gene, p = 9.8×10(-4), OR = 1.34; rs4872077, in TRAILR-1 gene, p = 0.005, OR = 1.72; and rs1001793 in TRAILR-2 gene, p = 0.012, OR = 0.84. The combination of the alleles G/T/A in these SNPs appears to be associated with a reduced risk of developing MS (p = 2.12×10(-5), OR = 0.59). These results suggest that genes of the TRAIL/TRAIL receptor system exerts a genetic influence on MS. http://hdl.handle.net/10668/489 http://hdl.handle.net/20.500.12105/17028 21814551 10.1371/journal.pone.0021766 1932-6203 PLoS ONE Adolescente Adulto Anciano Estudios de Casos y Controles Estudios de Cohortes Susceptibilidad a Enfermedades Femenino Genotipo Humanos Masculino Mediana Edad Multiple Esclerosis Polimorfismo de Nucleótido Simple Receptores del Ligando Inductor de Apoptosis Relacionado con TNF Ligando Inductor de Apoptosis Relacionado con TNF España Adulto Joven TRAIL/TRAIL Receptor System and Susceptibility to Multiple Sclerosis