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oai:repisalud.isciii.es:20.500.12105/170202024-11-28T14:43:23Zcom_20.500.12105_15322com_20.500.12105_2051col_20.500.12105_16927

00925njm 22002777a 4500 dc Mayas Torres, María Dolores author Ortega, Francisco J author Macías-González, Manuel author Bernal López, María Rosa author Gómez-Huelgas, Ricardo author Fernández-Real, José M author Tinahones Madueño, Francisco José author 2010-01-15 BACKGROUND: Adipose tissue is a key regulator of energy balance playing an active role in lipid storage and may be a dynamic buffer to control fatty acid flux. Just like PPARgamma, fatty acid synthesis enzymes such as FASN have been implicated in almost all aspects of human metabolic alterations such as obesity, insulin resistance or dyslipemia. The aim of this work is to investigate how FASN and PPARgamma expression in human adipose tissue is related to carbohydrate metabolism dysfunction and obesity. METHODS: The study included eighty-seven patients which were classified according to their BMI and to their glycaemia levels in order to study FASN and PPARgamma gene expression levels, anthropometric and biochemical variables. RESULTS: The main result of this work is the close relation between FASN expression level and the factors that lead to hyperglycemic state (increased values of glucose levels, HOMA-IR, HbA1c, BMI and triglycerides). The correlation of the enzyme with these parameters is inversely proportional. On the other hand, PPARgamma is not related to carbohydrate metabolism. CONCLUSIONS: We can demonstrate that FASN expression is a good candidate to study the pathophysiology of type II diabetes and obesity in humans. http://hdl.handle.net/10668/756 http://hdl.handle.net/20.500.12105/17020 20148112 10.1186/1743-7075-7-3 1743-7075 Nutrition & Metabolism Hiperglucemia Resistencia a la Insulina Obesidad Complejo Ácido Graso Sintetasa Índice de Masa Corporal Secuencia de bases Metabolismo de los Hidratos de Carbono Humanos Inverse relation between FASN expression in human adipose tissue and the insulin resistance level.