2026-07-21T08:44:12Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/169522025-11-28T13:00:57Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Bernardo, Lorena
author
Solana, Jose Carlos
author
Sanchez Herrero, Carmen
author
Torres Garcia, Ana Maria
author
Reyes-Cruz, Eder Yaveth
author
Carrillo, Eugenia
author
Moreno, Javier
funder
Instituto de Salud Carlos III
funder
Agencia Estatal de Investigación (España)
funder
Centro de Investigación Biomédica en Red - CIBERINFEC (Enfermedades Infecciosas)
2024-01-12T09:41:02Z
2024-01-12T09:41:02Z
2023
Front Immunol. 2023 Dec 1:14:1285943.
10.3389/fimmu.2023.1285943
1664-3224
Frontiers in immunology
http://hdl.handle.net/20.500.12105/16952
Background: Immunosuppression is a major risk factor for the development of visceral leishmaniasis (VL). The number of patients receiving immunosuppressant drugs such as TNF antagonist (anti-TNF) and methotrexate (MTX) is increasing. In these patients, VL is more severe, their response to treatment poorer, and they are at higher risk of relapse, a consequence (largely) of the poor and inappropriate immune response they develop. Objectives: To examine the effect of immunosuppressive treatment on the host immune response and thus gain insight into the reduced efficacy of pentavalent antimonials in these patients. Experiments were performed using BALB/c mice immunosuppressed with anti-TNF or MTX, infected with Leishmania infantum promastigotes, and then treated with Glucantime® at clinical doses. Results: Immunosuppression with both agents impeded parasite elimination from the spleen and bone marrow. Low pro-inflammatory cytokine production by CD4+ and CD8+ T cells was detected, along with an increase in PD-1 and IL-10 expression by B and T cells in the immunosuppressed groups after treatment. Conclusion: The immunosuppressed mice were unable to develop specific cellular immunity to the parasite, perhaps explaining the greater risk of VL relapse seen in pharmacologically immunosuppressed human patients.
eng
Visceral leishmaniasis
Immunosuppression
Immunosuppressants
BALB/c mice
TNF antagonist
Methotrexate
Glucantime®
Immunosuppressants alter the immune response associated with Glucantime® treatment for Leishmania infantum infection in a mouse model
research article
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ImmunosuppressantsAlterImmuneResponse_2023.pdf
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https://repisalud.isciii.es/bitstreams/7df27b6c-ca90-49a5-9f25-ad13e4998a85/download
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e496751c9d79c9f2a68c86eaf00bb547
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ImmunosuppressantsAlterImmuneResponse_2023.pdf.txt