2026-04-29T01:00:08Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/169492024-09-27T10:02:57Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Monzel, Anna S
author
Enriquez, Jose Antonio
author
Picard, Martin
2024-01-12T09:31:14Z
2024-01-12T09:31:14Z
2023-04
Nat Metab. 2023; 5(4):546-562
http://hdl.handle.net/20.500.12105/16949
37100996
10.1038/s42255-023-00783-1
2522-5812
Nature metabolism
Mitochondria have cell-type specific phenotypes, perform dozens of interconnected functions and undergo dynamic and often reversible physiological recalibrations. Given their multifunctional and malleable nature, the frequently used terms 'mitochondrial function' and 'mitochondrial dysfunction' are misleading misnomers that fail to capture the complexity of mitochondrial biology. To increase the conceptual and experimental specificity in mitochondrial science, we propose a terminology system that distinguishes between (1) cell-dependent properties, (2) molecular features, (3) activities, (4) functions and (5) behaviours. A hierarchical terminology system that accurately captures the multifaceted nature of mitochondria will achieve three important outcomes. It will convey a more holistic picture of mitochondria as we teach the next generations of mitochondrial biologists, maximize progress in the rapidly expanding field of mitochondrial science, and also facilitate synergy with other disciplines. Improving specificity in the language around mitochondrial science is a step towards refining our understanding of the mechanisms by which this unique family of organelles contributes to cellular and organismal health.
eng
Multifaceted mitochondria: moving mitochondrial science beyond function and dysfunction.
review article
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https://repisalud.isciii.es/bitstreams/a77e4145-e3de-4ebc-865a-ea0bb588d396/download
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Monzel-Multifaceted mitochondria- moving mitochondrial science beyond function and dysfunction-2023-Nature Metabolism.pdf
URL
https://repisalud.isciii.es/bitstreams/268515c0-8b51-4072-970c-3f5de1396db3/download
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Monzel-Multifaceted mitochondria- moving mitochondrial science beyond function and dysfunction-2023-Nature Metabolism.pdf.txt