2026-05-08T20:01:02Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/169462024-09-27T08:44:12Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Toribio-Fernandez, Raquel
author
Ceron, Carlos
author
Tristão-Pereira, Catarina
author
Fernandez-Nueda, Irene
author
Perez-Castillo, Ana
author
Fernandez-Ferro, Jose
author
Moro, Maria Angeles
author
Ibáñez, Borja
author
Fuster, Valentin
author
Cortes-Canteli, Marta
funder
Instituto de Salud Carlos III
funder
Unión Europea. Fondo Social Europeo (ESF/FSE)
funder
Fundación La Caixa
funder
Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)
2024-01-12T09:21:14Z
2024-01-12T09:21:14Z
2023-01-12
Br J Pharmacol . 2023 Jan 12.
10.1111/bph.16032
1476-5381
British journal of pharmacology
36633908
http://hdl.handle.net/20.500.12105/16946
Alzheimer's disease (AD) and cardiovascular disease (CVD) are strongly associated. Both are multifactorial disorders with long asymptomatic phases and similar risk factors. Indeed, CVD signatures such as cerebral microbleeds, micro-infarcts, atherosclerosis, cerebral amyloid angiopathy and a procoagulant state are highly associated with AD. However, AD and CVD co-development and the molecular mechanisms underlying such associations are not understood. Here, we review the evidence regarding the vascular component of AD and clinical studies using anticoagulants that specifically evaluated the development of AD and other dementias. Most studies reported a markedly decreased incidence of composite dementia in anticoagulated patients with atrial fibrillation, with the highest benefit for direct oral anticoagulants. However, sub-analyses by differential dementia diagnosis were scarce and inconclusive. We finally discuss whether anticoagulation could be a plausible preventive/therapeutic approach for AD and, if so, which would be the best drug and strategy to maximize clinical benefit and minimize potential risks.
eng
Oral anticoagulants: A plausible new treatment for Alzheimer's disease?
journal article
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Oral anticoagulants_Br J Pharmacol_2023.pdf
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https://repisalud.isciii.es/bitstreams/3e6c9d0d-1996-4512-80a6-828eccfa53a9/download
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Oral anticoagulants_Br J Pharmacol_2023.pdf.txt