2026-06-14T05:06:40Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/169052025-04-28T06:38:19Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19608col_20.500.12105_16963
Repisalud
author
Sotos-Prieto, Mercedes
author
Maroto-Rodriguez, Javier
author
Ortolá, Rosario
author
Martínez-Gómez, David
author
García-Esquinas, Esther
author
Buño-Soto, Antonio
author
Rodríguez-Artalejo, Fernando
funder
Instituto de Salud Carlos III
funder
Plan Nacional de I+D+i (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Plan Nacional de Drogas (España)
funder
Ministerio de Ciencia, Innovación y Universidades (España)
funder
Autonomous University of Madrid (España)
funder
Comunidad de Madrid (España)
funder
Fundación Soria Melguizo
2024-01-09T11:23:10Z
2024-01-09T11:23:10Z
2023-02-01
Free Radic Biol Med. 2023 Feb 1:195:192-198.
10.1016/j.freeradbiomed.2022.12.090
1873-4596
Free radical biology & medicine
36584798
http://hdl.handle.net/20.500.12105/16905
Background: Growth Differentiation Factor 15 (GDF-15) is a marker of inflammation and oxidative stress that has been associated with multiple age-related chronic diseases. Since lifestyle is key for preventing these adverse health outcomes, we examined the association between a Mediterranean lifestyle and GDF-15 serum concentrations in Spanish older adults. Methods: We used cross-sectional data from 2502 older adults participating in the Seniors ENRICA-2 cohort. Adherence to the Mediterranean lifestyle was assessed with the 27-item MEDLIFE index, divided into three blocks: 1) "Mediterranean food consumption, 2) Mediterranean dietary habits, 3) Physical activity, rest, social habits, and conviviality". Analyses of the association between the MEFLIFE index and GDF-15 concentrations were performed using multivariable linear regression models adjusting for the main potential confounders. Results: The MEDLIFE index was inversely associated with GDF-15. Compared with participants in the lowest quartile of the MEDLIFE score, GDF-15 mean percentage differences (95% CI) were -3.0% (-8.0, 2.3) for the second quartile, -8.7% (-13.0, -4.1) for the third quartile, and -10.1% (-15.0, -4.9) for the fourth quartile (p-trend<0.001). Block 3 of MEDLIFE, and particularly doing sufficient physical activity, adequate sleep duration, and participating in collective sports, was individually linked to lower concentrations of GDF-15. Results remained similar after excluding participants with cardiovascular disease, type 2 diabetes, or obesity. Conclusions: A Mediterranean lifestyle was associated with reduced levels of GDF-15, suggesting that a combination of multiple lifestyles may be an integral approach to reduce chronic inflammation and disease burden in older adults.
eng
Biomarkers
Physical activity
Diet index
Inflammaging
Association between a Mediterranean lifestyle and growth differentiation factor 15: The seniors ENRICA-2 cohort
research article
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