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oai:repisalud.isciii.es:20.500.12105/168882024-09-27T17:58:40Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19608

00925njm 22002777a 4500 dc Lamas, Gervasio A author Bhatnagar, Aruni author Jones, Miranda R author Mann, Koren K author Nasir, Khurram author Tellez-Plaza, Maria author Ujueta, Francisco author Navas-Acien, Ana author American Heart Association Council on Epidemiology and Prevention author Council on Cardiovascular and Stroke Nursing author Council on Lifestyle and Cardiometabolic Health author Council on Peripheral Vascular Disease author Council on the Kidney in Cardiovascular Disease author 2023-07-04 Exposure to environmental pollutants is linked to increased risk of cardiovascular disease. Beyond the extensive evidence for particulate air pollution, accumulating evidence supports that exposure to nonessential metals such as lead, cadmium, and arsenic is a significant contributor to cardiovascular disease worldwide. Humans are exposed to metals through air, water, soil, and food and extensive industrial and public use. Contaminant metals interfere with critical intracellular reactions and functions leading to oxidative stress and chronic inflammation that result in endothelial dysfunction, hypertension, epigenetic dysregulation, dyslipidemia, and changes in myocardial excitation and contractile function. Lead, cadmium, and arsenic have been linked to subclinical atherosclerosis, coronary artery stenosis, and calcification as well as to increased risk of ischemic heart disease and stroke, left ventricular hypertrophy and heart failure, and peripheral artery disease. Epidemiological studies show that exposure to lead, cadmium, or arsenic is associated with cardiovascular death mostly attributable to ischemic heart disease. Public health measures reducing metal exposure are associated with reductions in cardiovascular disease death. Populations of color and low socioeconomic means are more commonly exposed to metals and therefore at greater risk of metal-induced cardiovascular disease. Together with strengthening public health measures to prevent metal exposures, development of more sensitive and selective measurement modalities, clinical monitoring of metal exposures, and the development of metal chelation therapies could further diminish the burden of cardiovascular disease attributable to metal exposure. J Am Heart Assoc. 2023 Jul 4;12(13):e029852. 10.1161/JAHA.123.029852 2047-9980 Journal of the American Heart Association 37306302 http://hdl.handle.net/20.500.12105/16888 AHA Scientific Statements Arsenic Cadmium Cardiac risk factors Coronary disease Heavy metals Lead Myocardial infarction Contaminant Metals as Cardiovascular Risk Factors: A Scientific Statement From the American Heart Association