2026-04-29T12:23:37Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/168862025-04-04T16:08:34Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19608col_20.500.12105_16984

00925njm 22002777a 4500 dc Slowly, Monique author Domingo-Relloso, Arce author Santella, Regina M author Haack, Karin author Fallin, M Daniele author Terry, Mary Beth author Rhoades, Dorothy A author Herreros-Martinez, Miguel author García-Esquinas, Esther author Cole, Shelley A author Tellez-Plaza, Maria author Navas-Acien, Ana author Wu, Hui-Chen author 2024 Purpose: Liver cancer incidence among American Indians/Alaska Natives has risen over the past 20 years. Peripheral blood DNA methylation may be associated with liver cancer and could be used as a biomarker for cancer risk. We evaluated the association of blood DNA methylation with risk of liver cancer. Methods: We conducted a prospective cohort study in 2324 American Indians, between age 45 and 75 years, from Arizona, Oklahoma, North Dakota and South Dakota who participated in the Strong Heart Study between 1989 and 1991. Liver cancer deaths (n = 21) were ascertained using death certificates obtained through 2017. The mean follow-up duration (SD) for non-cases was 25.1 (5.6) years and for cases, 11.0 (8.8) years. DNA methylation was assessed from blood samples collected at baseline using MethylationEPIC BeadChip 850 K arrays. We used Cox regression models adjusted for age, sex, center, body mass index, low-density lipoprotein cholesterol, smoking, alcohol consumption, and immune cell proportions to examine the associations. Results: We identified 9 CpG sites associated with liver cancer. cg16057201 annotated to MRFAP1) was hypermethylated among cases vs. non-cases (hazard ratio (HR) for one standard deviation increase in methylation was 1.25 (95% CI 1.14, 1.37). The other eight CpGs were hypomethylated and the corresponding HRs (95% CI) ranged from 0.58 (0.44, 0.75) for cg04967787 (annotated to PPRC1) to 0.77 (0.67, 0.88) for cg08550308. We also assessed 7 differentially methylated CpG sites associated with liver cancer in previous studies. The adjusted HR for cg15079934 (annotated to LPS1) was 1.93 (95% CI 1.10, 3.39). Conclusions: Blood DNA methylation may be associated with liver cancer mortality and may be altered during the development of liver cancer. Cancer Causes Control. 2024 Apr;35(4):661-669. 10.1007/s10552-023-01822-8 1573-7225 Cancer causes & control : CCC 38010586 http://hdl.handle.net/20.500.12105/16886 American Indian Liver cancer Circulating leukocyte subtypes CpG site DNA methylation Strong Heart Study Blood DNA methylation and liver cancer in American Indians: evidence from the Strong Heart Study