2026-08-05T16:12:59Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/168672025-04-03T18:22:18Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19616
Repisalud
author
Ercetin, Evrim
author
Richtmann, Sarah
author
Martinez-Delgado, Beatriz
author
Gomez-Mariano, Gema Maria
author
Wrenger, Sabine
author
Korenbaum, Elena
author
Liu, Bin
author
DeLuca, David S
author
Kühnel, Mark P
author
Jonigk, Danny
author
Yuskaeva, Kadriya
author
Warth, Arne
author
Muley, Thomas
author
Winter, Hauke
author
Meister, Michael
author
Welte, Tobias
author
Janciauskiene, Sabina
author
Schneider, Marc A
funder
German Center for Lung Research (Alemania)
2023-12-21T18:48:37Z
2023-12-21T18:48:37Z
2019-09-04
Cancers (Basel). 2019 Sep 4;11(9):1306.
10.3390/cancers11091306
2072-6694
Cancers
31487965
http://hdl.handle.net/20.500.12105/16867
High expression of SERPINA1 gene encoding acute phase protein, alpha1-antitrypsin (AAT), is associated with various tumors. We sought to examine the significance of SERPINA1 and AAT protein in non-small-cell lung cancer (NSCLC) patients and NSCLC cell lines. Tumor and adjacent non-tumor lung tissues and serum samples from 351 NSCLC patients were analyzed for SERPINA1 expression and AAT protein levels. We also studied the impact of SERPINA1 expression and AAT protein on H1975 and H661 cell behavior, in vitro. Lower SERPINA1 expression in tumor but higher in adjacent non-tumor lung tissues (n = 351, p = 0.016) as well as higher serum levels of AAT protein (n = 170, p = 0.033) were associated with worse survival rates. Specifically, in NSCLC stage III patients, higher blood AAT levels (>2.66 mg/mL) correlated with a poor survival (p = 0.002). Intriguingly, levels of serum AAT do not correlate with levels of C-reactive protein, neutrophils-to-leukocyte ratio, and do not correlate with SERPINA1 expression or AAT staining in the tumor tissue. Additional experiments in vitro revealed that external AAT and/or overexpressed SERPINA1 gene significantly improve cancer cell migration, colony formation and resistance to apoptosis. SERPINA1 gene and AAT protein play an active role in the pathogenesis of lung cancer and not just reflect inflammatory reaction related to cancer development.
eng
alpha1-antitrypsin
SERPINA1
Lung cancer
Inflammation
Acute phase proteins
Apoptosis
Migration
Clinical Significance of SERPINA1 Gene and Its Encoded Alpha1-antitrypsin Protein in NSCLC
research article
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ClinicalSignificanceSERPINA1Gene_2023.pdf
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Figure_ClinicalSignificanceSERPINA1Gene_2023.pdf
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ClinicalSignificanceSERPINA1Gene_2023.pdf.txt
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Figure_ClinicalSignificanceSERPINA1Gene_2023.pdf.txt
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