2026-08-05T11:42:04Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/168452025-06-25T09:55:39Zcom_20.500.12105_15322com_20.500.12105_2051com_20.500.12105_2052col_20.500.12105_16990col_20.500.12105_19617col_20.500.12105_25179

00925njm 22002777a 4500 dc Carrero, Laura author Antequera, Desireé author Alcalde, Ignacio author Megías, Diego author Ordóñez-Gutiérrez, Lara author Gutierrez, Cristina author Merayo-Lloves, Jesús author Wandosell, Francisco author Municio, Cristina author Carro, Eva author 2023-10-27 Alzheimer's disease (AD), the most prevalent form of dementia, is a neurodegenerative disorder characterized by different pathological symptomatology, including disrupted circadian rhythm. The regulation of circadian rhythm depends on the light information that is projected from the retina to the suprachiasmatic nucleus in the hypothalamus. Studies of AD patients and AD transgenic mice have revealed AD retinal pathology, including amyloid-β (Aβ) accumulation that can directly interfere with the regulation of the circadian cycle. Although the cause of AD pathology is poorly understood, one of the main risk factors for AD is female gender. Here, we found that female APP/PS1 mice at 6- and 12-months old display severe circadian rhythm disturbances and retinal pathological hallmarks, including Aβ deposits in retinal layers. Since brain Aβ transport is facilitated by aquaporin (AQP)4, the expression of AQPs were also explored in APP/PS1 retina to investigate a potential correlation between retinal Aβ deposits and AQPs expression. Important reductions in AQP1, AQP4, and AQP5 were detected in the retinal tissue of these transgenic mice, mainly at 6-months of age. Taken together, our findings suggest that abnormal transport of Aβ, mediated by impaired AQPs expression, contributes to the retinal degeneration in the early stages of AD. Int J Mol Sci. 2023 Oct 27;24(21):15679. 10.3390/ijms242115679 1422-0067 International journal of molecular sciences 37958666 http://hdl.handle.net/20.500.12105/16845 Alzheimer’s disease Circadian rhythm Clock genes Retina Transgenic mice Hypothalamus Cerebral cortex Hippocampus Amyloid Altered Clock Gene Expression in Female APP/PS1 Mice and Aquaporin-Dependent Amyloid Accumulation in the Retina