2026-06-14T03:51:43Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/168352024-11-28T17:54:12Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16961
Repisalud
author
Rodríguez-Agustín, Andrea
author
Casanova, Víctor
author
Grau-Expósito, Judith
author
Sánchez-Palomino, Sonsoles
author
Alcamí, José
author
Climent, Núria
funder
Gilead Sciences (Spain)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Instituto de Salud Carlos III
funder
Government of Catalonia (España)
funder
Fundación La Caixa
funder
Centro de Investigación Biomédica en Red - CIBERINFEC (Enfermedades Infecciosas)
funder
RETICS-Sida (RIS-ISCIII) (España)
funder
RIS
2023-12-18T13:55:31Z
2023-12-18T13:55:31Z
2023-03-11
Pharmaceutics. 2023 Mar 11;15(3):917.
10.3390/pharmaceutics15030917
1999-4923
Pharmaceutics
36986778
http://hdl.handle.net/20.500.12105/16835
Tyrosine kinase inhibitors (TKIs) have been extensively used as a treatment for chronic myeloid leukemia (CML). Dasatinib is a broad-spectrum TKI with off-target effects that give it an immunomodulatory capacity resulting in increased innate immune responses against cancerous cells and viral infected cells. Several studies reported that dasatinib expanded memory-like natural killer (NK) cells and γδ T cells that have been related with increased control of CML after treatment withdrawal. In the HIV infection setting, these innate cells are associated with virus control and protection, suggesting that dasatinib could have a potential role in improving both the CML and HIV outcomes. Moreover, dasatinib could also directly induce apoptosis of senescence cells, being a new potential senolytic drug. Here, we review in depth the current knowledge of virological and immunogenetic factors associated with the development of powerful cytotoxic responses associated with this drug. Besides, we will discuss the potential therapeutic role against CML, HIV infection and aging.
eng
Dasatinib
Tyrosine kinase inhibitors
CML
Cancer
HIV-1
CMV
HIV functional cure
Memory-like NK cells
γδ T cells
Anti-aging
Senolytic
Immunomodulatory Activity of the Tyrosine Kinase Inhibitor Dasatinib to Elicit NK Cytotoxicity against Cancer, HIV Infection and Aging
review article
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ImmunomodulatoryActivityTyrosineKinase_2023.pdf
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ImmunomodulatoryActivityTyrosineKinase_2023.pdf.txt