2026-08-05T15:04:39Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/168232026-05-08T20:51:07Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_25179
Repisalud
author
Asensio-Cob, Dunia
author
Rodríguez, Javier M
author
Luque, Daniel
funder
Instituto de Salud Carlos III
funder
Ministerio de Ciencia e Innovación (España)
2023-12-15T19:18:14Z
2023-12-15T19:18:14Z
2023-08-16
Viruses. 2023 Aug 16;15(8):1750.
10.3390/v15081750
1999-4915
Viruses
37632092
http://hdl.handle.net/20.500.12105/16823
Rotaviruses (RVs) are non-enveloped multilayered dsRNA viruses that are major etiologic agents of diarrheal disease in humans and in the young in a large number of animal species. The viral particle is composed of three different protein layers that enclose the segmented dsRNA genome and the transcriptional complexes. Each layer defines a unique subparticle that is associated with a different phase of the replication cycle. Thus, while single- and double-layered particles are associated with the intracellular processes of selective packaging, genome replication, and transcription, the viral machinery necessary for entry is located in the third layer. This modular nature of its particle allows rotaviruses to control its replication cycle by the disassembly and assembly of its structural proteins. In this review, we examine the significant advances in structural, molecular, and cellular RV biology that have contributed during the last few years to illuminating the intricate details of the RV particle disassembly and assembly processes.
eng
dsRNA virus
Reovirus
Rotavirus
Virus assembly
Virus structure
Rotavirus Particle Disassembly and Assembly In Vivo and In Vitro
review article
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URL
https://repisalud.isciii.es/bitstreams/8d3f0d96-d498-433d-b23f-bfa2df9de13a/download
File
MD5
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application/pdf
RotavirusParticleDisassemblyAssembly_2023.pdf
URL
https://repisalud.isciii.es/bitstreams/2e7f8922-1bb7-448c-a629-99e1f738b337/download
File
MD5
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text/plain
RotavirusParticleDisassemblyAssembly_2023.pdf.txt