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oai:repisalud.isciii.es:20.500.12105/168232026-05-08T20:51:07Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_25179

00925njm 22002777a 4500 dc Asensio-Cob, Dunia author Rodríguez, Javier M author Luque, Daniel author 2023-08-16 Rotaviruses (RVs) are non-enveloped multilayered dsRNA viruses that are major etiologic agents of diarrheal disease in humans and in the young in a large number of animal species. The viral particle is composed of three different protein layers that enclose the segmented dsRNA genome and the transcriptional complexes. Each layer defines a unique subparticle that is associated with a different phase of the replication cycle. Thus, while single- and double-layered particles are associated with the intracellular processes of selective packaging, genome replication, and transcription, the viral machinery necessary for entry is located in the third layer. This modular nature of its particle allows rotaviruses to control its replication cycle by the disassembly and assembly of its structural proteins. In this review, we examine the significant advances in structural, molecular, and cellular RV biology that have contributed during the last few years to illuminating the intricate details of the RV particle disassembly and assembly processes. Viruses. 2023 Aug 16;15(8):1750. 10.3390/v15081750 1999-4915 Viruses 37632092 http://hdl.handle.net/20.500.12105/16823 dsRNA virus Reovirus Rotavirus Virus assembly Virus structure Rotavirus Particle Disassembly and Assembly In Vivo and In Vitro