2026-06-14T03:53:27Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/168222025-06-25T09:50:25Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609
Repisalud
author
Rodon, Jordi
author
Sachse, Martin
author
Te, Nigeer
author
Segalés, Joaquim
author
Bensaid, Albert
author
Risco, Cristina
author
Vergara-Alert, Júlia
funder
Ministerio de Ciencia e Innovación (España)
funder
Government of Catalonia (España)
funder
Unión Europea. Comisión Europea. H2020
funder
Unión Europea. Comisión Europea. 7 Programa Marco
2023-12-15T19:09:07Z
2023-12-15T19:09:07Z
2024
Microbes Infect. 2024 Mar-Apr;26(3):105252.
10.1016/j.micinf.2023.105252
1769-714X
Microbes and infection
37981029
http://hdl.handle.net/20.500.12105/16822
Severe Middle East respiratory syndrome (MERS) is characterized by massive infiltration of immune cells in lungs. MERS-coronavirus (MERS-CoV) replicates in vitro in human macrophages, inducing high pro-inflammatory responses. In contrast, camelids, the main reservoir for MERS-CoV, are asymptomatic carriers. Although limited infiltration of leukocytes has been observed in the lower respiratory tract of camelids, their role during infection remains unknown. Here we studied whether llama alveolar macrophages (LAMs) are susceptible to MERS-CoV infection and can elicit pro-inflammatory responses. MERS-CoV did not replicate in LAMs; however, they effectively capture and degrade viral particles. Moreover, transcriptomic analyses showed that LAMs do not induce pro-inflammatory cytokines upon MERS-CoV sensing.
eng
Alveolar macrophages
Immune responses
Llama
MERS-CoV
Middle East respiratory syndrome coronavirus
Pro-inflammatory cytokines
Middle East respiratory coronavirus (MERS-CoV) internalized by llama alveolar macrophages does not result in virus replication or induction of pro-inflammatory cytokines
research article
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