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oai:repisalud.isciii.es:20.500.12105/168222025-06-25T09:50:25Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc Rodon, Jordi author Sachse, Martin author Te, Nigeer author Segalés, Joaquim author Bensaid, Albert author Risco, Cristina author Vergara-Alert, Júlia author 2024 Severe Middle East respiratory syndrome (MERS) is characterized by massive infiltration of immune cells in lungs. MERS-coronavirus (MERS-CoV) replicates in vitro in human macrophages, inducing high pro-inflammatory responses. In contrast, camelids, the main reservoir for MERS-CoV, are asymptomatic carriers. Although limited infiltration of leukocytes has been observed in the lower respiratory tract of camelids, their role during infection remains unknown. Here we studied whether llama alveolar macrophages (LAMs) are susceptible to MERS-CoV infection and can elicit pro-inflammatory responses. MERS-CoV did not replicate in LAMs; however, they effectively capture and degrade viral particles. Moreover, transcriptomic analyses showed that LAMs do not induce pro-inflammatory cytokines upon MERS-CoV sensing. Microbes Infect. 2024 Mar-Apr;26(3):105252. 10.1016/j.micinf.2023.105252 1769-714X Microbes and infection 37981029 http://hdl.handle.net/20.500.12105/16822 Alveolar macrophages Immune responses Llama MERS-CoV Middle East respiratory syndrome coronavirus Pro-inflammatory cytokines Middle East respiratory coronavirus (MERS-CoV) internalized by llama alveolar macrophages does not result in virus replication or induction of pro-inflammatory cytokines