2026-04-29T02:37:35Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/167882024-11-29T11:11:49Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19608col_20.500.12105_16981

00925njm 22002777a 4500 dc Ojeda Sánchez, Carlos author García-Pérez, Javier author Gomez-Barroso, Diana author Domínguez-Castillo, Alejandro author Pardo Romaguera, Elena author Cañete, Adela author Ortega-García, Juan Antonio author Ramis, Rebeca author 2023-01-31 Background: Several environmental factors seem to be involved in childhood leukaemia incidence. Traffic exposure could increase the risk while urban green spaces (UGS) exposure could reduce it. However, there is no evidence how these two factors interact on this infant pathology. Objectives: to evaluate how residential proximity to UGS could be an environmental protective factor against traffic exposure on childhood leukaemia incidence. Methods: A population-based case control study was conducted across thirty Spanish regions during the period 2000-2018. It included 2526 incident cases and 15,156, individually matched by sex, year-of-birth, and place-of-residence. Using the geographical coordinates of the participants' home residences, a 500 m proxy for exposure to UGS was built. Annual average daily traffic (AADT) was estimated for all types of roads 100 m near the children's residence. Odds ratios (ORs) and 95% confidence intervals (95% CIs), UGS, traffic exposure, and their possible interactions were calculated for overall childhood leukaemia, and the acute lymphoblastic (ALL) and acute myeloblastic leukaemia (AML) subtypes, with adjustment for socio-demographic covariates. Results: We found an increment of childhood leukaemia incidence related to traffic exposure, for every 100 AADT increase the incidence raised 1.1% (95% CI: 0.58-1.61%). UGS exposure showed an incidence reduction for the highest exposure level, Q5 (OR = 0.63; 95% CI = 0.54-0.72). Regression models with both traffic exposure and UGS exposure variables showed similar results but the interaction was not significant. Conclusions: Despite their opposite effects on childhood leukaemia incidence individually, our results do not suggest a possible interaction between both exposures. This is the first study about the interaction of these two environmental factors; consequently, it is necessary to continue taking into account more individualized data and other possible environmental risk factors involved. Int J Environ Res Public Health. 2023 Jan 31;20(3):2506. http://hdl.handle.net/20.500.12105/16788 36767873 10.3390/ijerph20032506 1660-4601 International journal of environmental research and public health Urban green spaces Traffic exposure Environmental factors Childhood cancer Childhood leukaemia Incidence Spatial epidemiology Exploring Urban Green Spaces' Effect against Traffic Exposure on Childhood Leukaemia Incidence