2026-06-14T03:44:56Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/167802024-09-27T08:46:01Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Lalaguna, Laura
author
Ramos-Hernandez, Laura
author
Priori, Silvia G.
author
Lara-Pezzi, Enrique
2023-12-12T12:00:42Z
2023-12-12T12:00:42Z
2023
Adv Exp Med Biol . 2023:1396:115-127.
10.1007/978-981-19-5642-3_8
0065-2598
Advances in experimental medicine and biology
36454463
http://hdl.handle.net/20.500.12105/16780
Inherited arrhythmic disorders are a group of heterogeneous diseases predisposing to life-threatening arrhythmias and sudden cardiac death. Their diagnosis is not always simple due to incomplete penetrance and genetic heterogeneity. Furthermore, the available treatments are usually invasive and merely preventive. Genome editing and especially CRISPR/Cas9 technologies have the potential to correct the genetic arrhythmogenic substrate, thereby offering a cure for these fatal diseases. To date, genome editing has allowed reproducing cardiac arrhythmias in vitro, providing a robust platform for variant pathogenicity, mechanistic, and drug-testing studies. However, in vivo approaches still need profound research regarding safety, specificity, and efficiency of the methods.
eng
Genome Editing and Inherited Cardiac Arrhythmias.
other
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URL
https://repisalud.isciii.es/bitstreams/3d13a91b-751d-424f-9afc-b865f9bf5735/download
File
MD5
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application/pdf
Genome Editing and Inherited_ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY_2023.pdf
URL
https://repisalud.isciii.es/bitstreams/ec787f61-a109-418f-ab75-1c3012839955/download
File
MD5
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text/plain
Genome Editing and Inherited_ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY_2023.pdf.txt