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oai:repisalud.isciii.es:20.500.12105/167542025-04-23T11:25:49Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19610
Repisalud author Rodriguez Martin, Laura author Gilles, Liese author Helte, Emilie author Åkesson, Agneta author Tägt, Jonas author Covaci, Adrian author Sakhi, Amrit K author Van Nieuwenhuyse, An author Katsonouri, Andromachi author Andersson, Anna-Maria author Gutleb, Arno C author Janasik, Beata author Appenzeller, Brice author Gabriel, Catherine author Thomsen, Cathrine author Mazej, Darja author Sarigiannis, Denis author Anastasi, Elena author Barbone, Fabio author Tolonen, Hanna author Frederiksen, Hanne author Klánová, Jana author Koponen, Jani author Tratnik, Janja Snoj author Pack, Kim author Gudrun, Koppen author Ólafsdóttir, Kristin author Knudsen, Lisbeth E author Rambaud, Loïc author Strumylaite, Loreta author Palkovicova Murinova, Lubica author Fábelová, Lucia author Riou, Margaux author Berglund, Marika author Szabados, Maté author Imboden, Medea author Laeremans, Michelle author Eštóková, Milada author Janev Holcer, Natasa author Probst-Hensch, Nicole author Vodrazkova, Nicole author Vogel, Nina author Piler, Pavel author Schmidt, Phillipp author Lange, Rosa author Namorado, Sónia author Középesy, Szilvia author Szigeti, Tamás author Halldórsson, Thórhallur Ingi author Weber, Till author Jensen, Tina Kold author Rosolen, Valentina author Puklova, Vladimira author Wasowicz, Wojciech author Sepai, Ovnair author Stewart, Lorraine author Kolossa-Gehring, Marike author Esteban-Lopez, Marta author Castaño, Argelia author Bessems, Jos author Schoeters, Greet author Govarts, Eva funder Unión Europea. Comisión Europea. H2020 2023-12-05T10:05:44Z 2023-12-05T10:05:44Z 2023-09-28 Toxics. 2023 Sep 28;11(10):819. 10.3390/toxics11100819 2305-6304 Toxics 37888670 http://hdl.handle.net/20.500.12105/16754 Human biomonitoring (HBM) data in Europe are often fragmented and collected in different EU countries and sampling periods. Exposure levels for children and adult women in Europe were evaluated over time. For the period 2000-2010, literature and aggregated data were collected in a harmonized way across studies. Between 2011-2012, biobanked samples from the DEMOCOPHES project were used. For 2014-2021, HBM data were generated within the HBM4EU Aligned Studies. Time patterns on internal exposure were evaluated visually and statistically using the 50th and 90th percentiles (P50/P90) for phthalates/DINCH and organophosphorus flame retardants (OPFRs) in children (5-12 years), and cadmium, bisphenols and polycyclic aromatic hydrocarbons (PAHs) in women (24-52 years). Restricted phthalate metabolites show decreasing patterns for children. Phthalate substitute, DINCH, shows a non-significant increasing pattern. For OPFRs, no trends were statistically significant. For women, BPA shows a clear decreasing pattern, while substitutes BPF and BPS show an increasing pattern coinciding with the BPA restrictions introduced. No clear patterns are observed for PAHs or cadmium. Although the causal relations were not studied as such, exposure levels to chemicals restricted at EU level visually decreased, while the levels for some of their substitutes increased. The results support policy efficacy monitoring and the policy-supportive role played by HBM. eng Human biomonitoring Hazardous chemical Phthalates DINCH OPFRs Cadmium PAHs Bisphenols Time Patterns in Internal Human Exposure Data to Bisphenols, Phthalates, DINCH, Organophosphate Flame Retardants, Cadmium and Polyaromatic Hydrocarbons in Europe research article 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 URL https://repisalud.isciii.es/bitstreams/e1fe231c-b950-41a0-8655-b09f73b040b9/download File MD5 9cd25932617ae2647ef6e96248339d24 3163983 application/pdf TimePatternsInternalHuman_2023.pdf URL https://repisalud.isciii.es/bitstreams/c5b83aa1-428c-417f-9ee5-800b182818e3/download File MD5 053ddc82694c15d9658da8e93c04cbe3 849940 application/pdf Supplementary_TimePatternsInternalHuman_2023.pdf URL https://repisalud.isciii.es/bitstreams/a32e8215-5e75-40e1-a612-968c30f5f4aa/download File MD5 b90f6c59479978ed4ab6a24a9a219c2d 97722 text/plain TimePatternsInternalHuman_2023.pdf.txt URL https://repisalud.isciii.es/bitstreams/6932145a-3787-434e-ade4-f9a0bcfdbeb8/download File MD5 5890ec79965b94fea1c638b3608bd4ba 30999 text/plain Supplementary_TimePatternsInternalHuman_2023.pdf.txt