2026-07-21T10:00:18Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/167492025-04-07T13:08:29Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19608col_20.500.12105_16974col_20.500.12105_16987col_20.500.12105_16988col_20.500.12105_16990
Repisalud
author
Suárez-García, I
author
Gutierrez, Félix
author
Pérez-Molina, José A
author
Moreno, Santiago
author
Aldámiz-Echevarria, Teresa
author
Valencia Ortega, Eulalia
author
Curran, Adrián
author
Gutiérrez González, Sara
author
Asensi, Víctor
author
Amador Prous, Concha
author
Jarrin Vera, Inmaculada
author
Rava, Marta
author
CoRIS Cohort
funder
Conferencia de Rectores de las Universidades Españolas
funder
Consejo Superior de Investigaciones Científicas (España)
funder
Instituto de Salud Carlos III
funder
Ministerio de Ciencia e Innovación (España)
funder
Unión Europea. Comisión Europea. NextGenerationEU
funder
Gilead Sciences (Spain)
funder
Centro de Investigación Biomédica en Red - CIBERINFEC (Enfermedades Infecciosas)
2023-12-05T09:05:47Z
2023-12-05T09:05:47Z
2023-11-26
J Cancer Res Clin Oncol. 2023 Nov 26.
10.1007/s00432-023-05500-9
1432-1335
Journal of cancer research and clinical oncology
38008809
http://hdl.handle.net/20.500.12105/16749
Purpose: Our aim was to describe non-AIDS-defining cancer (NADC) mortality among people living with HIV (PLWH), to compare it with that of the general population, and to assess potential risk factors. Methods: We included antiretroviral-naive PLWH from the multicentre CoRIS cohort (2004-2021). We estimated mortality rates and standardised mortality ratios (SMRs). We used cause-specific Cox models to identify risk factors. Results: Among 17,978 PLWH, NADC caused 21% of all deaths observed during the follow-up. Mortality rate due to NADC was 1.58 (95%CI 1.36, 1.83) × 1000 person-years and lung and liver were the most frequent cancer-related causes of death. PLWH had 79% excess NADC mortality risk compared to the general population with the highest SMR found for Hodgkin lymphoma, anal and liver cancers. The SMRs decreased with age and were the highest in age groups under 50 years. The most important prognostic factor was low CD4 count, followed by smoking, viral hepatitis and HIV transmission through heterosexual contact or injection drug use. Conclusion: Non-AIDS cancers are an important cause of death among PLWH. The excess mortality related to certain malignancies and the association with immunodeficiency, smoking, and coinfections highlights the need for early detection and treatment of cancer in this population.
eng
Cancer
Mortality
HIV
Cohort study
Mortality due to non-AIDS-defining cancers among people living with HIV in Spain over 18 years of follow-up
research article
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