2026-07-21T10:00:18Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/167492025-04-07T13:08:29Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19608col_20.500.12105_16974col_20.500.12105_16987col_20.500.12105_16988col_20.500.12105_16990

00925njm 22002777a 4500 dc Suárez-García, I author Gutierrez, Félix author Pérez-Molina, José A author Moreno, Santiago author Aldámiz-Echevarria, Teresa author Valencia Ortega, Eulalia author Curran, Adrián author Gutiérrez González, Sara author Asensi, Víctor author Amador Prous, Concha author Jarrin Vera, Inmaculada author Rava, Marta author CoRIS Cohort author 2023-11-26 Purpose: Our aim was to describe non-AIDS-defining cancer (NADC) mortality among people living with HIV (PLWH), to compare it with that of the general population, and to assess potential risk factors. Methods: We included antiretroviral-naive PLWH from the multicentre CoRIS cohort (2004-2021). We estimated mortality rates and standardised mortality ratios (SMRs). We used cause-specific Cox models to identify risk factors. Results: Among 17,978 PLWH, NADC caused 21% of all deaths observed during the follow-up. Mortality rate due to NADC was 1.58 (95%CI 1.36, 1.83) × 1000 person-years and lung and liver were the most frequent cancer-related causes of death. PLWH had 79% excess NADC mortality risk compared to the general population with the highest SMR found for Hodgkin lymphoma, anal and liver cancers. The SMRs decreased with age and were the highest in age groups under 50 years. The most important prognostic factor was low CD4 count, followed by smoking, viral hepatitis and HIV transmission through heterosexual contact or injection drug use. Conclusion: Non-AIDS cancers are an important cause of death among PLWH. The excess mortality related to certain malignancies and the association with immunodeficiency, smoking, and coinfections highlights the need for early detection and treatment of cancer in this population. J Cancer Res Clin Oncol. 2023 Nov 26. 10.1007/s00432-023-05500-9 1432-1335 Journal of cancer research and clinical oncology 38008809 http://hdl.handle.net/20.500.12105/16749 Cancer Mortality HIV Cohort study Mortality due to non-AIDS-defining cancers among people living with HIV in Spain over 18 years of follow-up