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00925njm 22002777a 4500 dc Sánchez-Álvarez, Miguel author del Pozo, Miguel Angel author 2022-05-02 Programmed cell death-ligand 1 (PD-L1)-mediated T cell inhibition through PD-1 is a key checkpoint frequently exploited by tumors to evade immunity. In this issue, Wang et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202108083) reveal an unexpected role for PD-L1 in promoting tumor cell front-rear polarity and directionally persistent cell migration, independently of PD-1. J Cell Biol. 2022 May 2;221(5):e202203137. http://hdl.handle.net/20.500.12105/16740 35416931 10.1083/jcb.202203137 1540-8140 The Journal of cell biology An unexpected role for PD-L1 in front-rear polarization and directional migration.