2026-06-14T03:45:12Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/167322024-11-28T16:43:03Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16958col_20.500.12105_16970col_20.500.12105_16978
Repisalud
author
Martín-Escolano, Rubén
author
Vidal-Alcántara, Erick Joan
author
Crespo, Javier
author
Ryan, Pablo
author
Real, Luis Miguel
author
Lazo-Álvarez, Juan Ignacio
author
Cabezas-González, Joaquín
author
Macías, Juan
author
Arias-Loste, María Teresa
author
Cuevas, Guillermo
author
Virseda-Berdices, Ana
author
Briz, Veronica
author
Resino, Salvador
author
Jimenez-Sousa, Maria Angeles
author
Fernandez-Rodriguez, Amanda
funder
Instituto de Salud Carlos III
funder
Fundación Universidad Alfonso X el Sabio
funder
Fundación Banco Santander
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Ministerio de Ciencia e Innovación (España)
funder
Centro de Investigación Biomédica en Red - CIBERINFEC (Enfermedades Infecciosas)
funder
Unión Europea. Comisión Europea. NextGenerationEU
funder
Agencia Estatal de Investigación (España)
2023-11-27T10:00:32Z
2023-11-27T10:00:32Z
2023-11-17
Immun Ageing. 2023 Nov 17;20(1):62.
10.1186/s12979-023-00387-z
1742-4933
Immunity & ageing : I & A
37978401
http://hdl.handle.net/20.500.12105/16732
Background: About 25% of patients with acute hepatitis C virus (HCV) infection show spontaneous clearance within the first six months of infection but may remain at risk of inflammaging, aging, and liver and non-liver disease complications. This study evaluated the differences in the plasma levels of immune checkpoints (ICs) and senescence-associated secretory phenotype (SASP) biomarkers between patients who had spontaneously eliminated HCV infection (SC group) and individuals without evidence of HCV infection (C group). Methods: We performed a multicenter retrospective study of 56 individuals: 32 in the SC and 24 in the C groups. ICs and SASP proteins were analyzed using a Luminex 200TM analyzer. The statistical analysis used Generalized Linear Models with gamma distribution (log-link) adjusted by significant variables and sex. Results: 13 ICs (BTLA, CD137(4-1BB), CD27, CD28, CD80, GITR, HVEM, IDO, LAG-3, PD-1, PD-L1, PD-L2, and TIM-3) and 13 SASP proteins (EGF, Eotaxin, IL-1alpha, IL-1RA, IL-8, IL-13, IL-18, IP-10, SDF-1alpha, HGF, beta-NGF, PLGF-1, and SCF) were significantly higher in SC group after approximately more than two years of HCV clearance. After stratifying by sex, differences remained significant for males, which showed higher levels for 13 ICs and 4 SASP proteins in SC. While only PD-L2 was significantly higher in SC women, and no differences in SASP were found. Conclusions: Higher plasma levels of different IC and SASP proteins were found in individuals after more than two years of HCV clearance, mainly in men. Alterations in these molecules might be associated with an increased risk of developing liver and non-hepatic diseases.
eng
Biomarkers
HCV
Immune checkpoint proteins
SASP proteins
Spontaneous clearance
Immunological and senescence biomarker profiles in patients after spontaneous clearance of hepatitis C virus: gender implications for long-term health risk
research article
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