2026-06-14T03:54:59Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/167312024-11-28T18:51:55Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16963col_20.500.12105_16964
Repisalud
author
Romera Martínez, Irene
author
Avendaño-Solá, Cristina
author
Villegas Da Ros, Carolina
author
Bosch Llobet, Alba
author
García Erce, José Antonio
author
González Fraile, María Isabel
author
Guerra Domínguez, Luisa
author
Vicuña Andrés, Isabel
author
Anguita Velasco, Javier
author
González Rodríguez, Victoria Paz
author
Contreras, Enric
author
Urcelay Uranga, Sabin
author
Pajares Herraiz, Ángel Luis
author
Jimenez-Marco, Teresa
author
Ojea Pérez, Ana María
author
Arroyo Rodríguez, José Luis
author
Perez-Olmeda, Mayte
author
Ramos-Martínez, Antonio
author
Velasco-Iglesias, Ana
author
Bueno Cabrera, José Luis
author
Duarte, Rafael F
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Ministerio de Ciencia e Innovación (España)
funder
Instituto de Salud Carlos III
2023-11-27T09:28:20Z
2023-11-27T09:28:20Z
2024
Vox Sang. 2024 Jan;119(1):27-33.
10.1111/vox.13561
1423-0410
Vox sanguinis
37986640
http://hdl.handle.net/20.500.12105/16731
Background and objectives: The efficacy of COVID-19 convalescent plasma (CP) associates with high titres of antibodies. ConPlas-19 clinical trial showed that CP reduces the risk of progression to severe COVID-19 at 28 days. Here, we aim to study ConPlas-19 donors and characteristics that associate with high anti-SARS-CoV-2 antibody levels. Materials and methods: Four-hundred donors were enrolled in ConPlas-19. The presence and titres of anti-SARS-CoV-2 antibodies were evaluated by EUROIMMUN anti-SARS-CoV-2 S1 IgG ELISA. Results: A majority of 80.3% of ConPlas-19 donor candidates had positive EUROIMMUN test results (ratio ≥1.1), and of these, 51.4% had high antibody titres (ratio ≥3.5). Antibody levels decline over time, but nevertheless, out of 37 donors tested for an intended second CP donation, over 90% were still EUROIMMUN positive, and nearly 75% of those with high titres maintained high titres in the second sample. Donors with a greater probability of developing high titres of anti-SARS-CoV-2 antibodies include those older than 40 years of age (RR 2.06; 95% CI 1.24-3.42), with more than 7 days of COVID-19 symptoms (RR 1.89; 95% CI 1.05-3.43) and collected within 4 months from infection (RR 2.61; 95% CI 1.16-5.90). Male donors had a trend towards higher titres compared with women (RR 1.67; 95% CI 0.91-3.06). Conclusion: SARS-CoV-2 CP candidate donors' age, duration of COVID-19 symptoms and time from infection to donation associate with the collection of CP with high antibody levels. Beyond COVID-19, these data are relevant to inform decisions to optimize the CP donor selection process in potential future outbreaks.
eng
anti-SARS-CoV-2
Convalescent plasma
COVID-19
Donors
Passive immunotherapy
Factors related to the development of high antibody titres against SARS-CoV-2 in convalescent plasma donors from the ConPlas-19 trial
research article
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URL
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FactorsRelatedDevelopmentHighAntibody_2024.pdf
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FactorsRelatedDevelopmentHighAntibody_2023.pdf.txt
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https://repisalud.isciii.es/bitstreams/df084f75-7956-4237-ab84-65c210d38be9/download
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FactorsRelatedDevelopmentHighAntibody_2024.pdf.txt