2026-07-21T07:57:51Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/166672024-11-28T19:25:03Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16964
Repisalud
author
Caballero-Bermejo, Antonio F
author
Darnaude-Ximénez, Ignacio
author
Aguilar-Pérez, Myriam
author
Gomez-Lopez, Alicia
author
Sancho-López, Aránzazu
author
López García-Gallo, Cristina
author
Díaz Nuevo, Gema
author
Diago-Sempere, Elena
author
Ruiz-Antorán, Belén
author
Avendaño-Solá, Cristina
author
Ussetti-Gil, Piedad
author
PBISA01-Study Group
funder
Pfizer
2023-11-14T11:19:18Z
2023-11-14T11:19:18Z
2023-10-18
Antimicrob Agents Chemother. 2023 Oct 18;67(10):e0061323.
10.1128/aac.00613-23
1098-6596
Antimicrobial agents and chemotherapy
37787528
http://hdl.handle.net/20.500.12105/16667
Isavuconazole's (ISA) pharmacokinetics was studied among lung transplant recipients to evaluate its bronchopulmonary penetration. This study included 13 patients and showed mean serum concentrations of 3.30 (standard deviation [SD] 0.45), 5.12 (SD 1.36), and 6.31 (SD 0.95) at 2 h, 4 h, and 24 h respectively. Mean concentrations in the epithelial lining fluid were 0.969 (SD 0.895), 2.141 (SD 1.265), and 2.812 (SD 0.693) at the same time points. ISA is a drug with a tolerable safety profile that achieves adequate concentrations in the lung.
eng
Isavuconazole
Invasive fungal infection
Bronchoalveolar lavage
Tissue penetration
Lung transplant
Bronchopulmonary penetration of isavuconazole in lung transplant recipients
research article
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BronchopulmonaryPenetrationIsavuconazoleLung_2023.pdf
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Supplementary1_BronchopulmonaryPenetrationIsavuconazoleLung_2023.pdf
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BronchopulmonaryPenetrationIsavuconazoleLung_2023.pdf.txt
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Supplementary1_BronchopulmonaryPenetrationIsavuconazoleLung_2023.pdf.txt
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Supplementary2_BronchopulmonaryPenetrationIsavuconazoleLung_2023.pdf.txt