2026-04-29T07:25:40Zhttps://repisalud.isciii.es/rest/oai/request

oai:repisalud.isciii.es:20.500.12105/166122024-09-27T23:43:54Zcom_20.500.12105_2052com_20.500.12105_2051col_20.500.12105_19609

00925njm 22002777a 4500 dc de la Varga-Martínez, Olga author Martín-Fernández, Marta author Heredia-Rodríguez, María author Ceballos, Francisco C author Cubero-Gallego, Hector author Priede-Vimbela, Juan Manuel author Bardají-Carrillo, Miguel author Sánchez-de Prada, Laura author López-Herrero, Rocío author Jorge-Monjas, Pablo author Tamayo, Eduardo author Gómez-Sánchez, Esther author 2022-12-07 Background: procalcitonin is a valuable marker in the diagnosis of bacterial infections; however, the impairment of renal function can influence its diagnostic precision. The objective of this study is to evaluate the differential behaviour of procalcitonin, as well as its usefulness in the diagnosis of postoperative pulmonary infection after cardiac surgery, depending on the presence or absence of impaired renal function. Materials and methods: A total of 805 adult patients undergoing cardiac surgery with extracorporeal circulation (CBP) were prospectively recruited, comparing the behaviour of biomarkers between the groups with and without postoperative pneumonia and according to the presence or absence of renal dysfunction. Results: Pulmonary infection was diagnosed in 42 patients (5.21%). In total, 228 patients (28.32%) presented postoperative renal dysfunction. Procalcitonin was significantly higher in infected patients, even in the presence of renal dysfunction. The optimal procalcitonin threshold differed markedly in patients with renal dysfunction compared to patients without renal dysfunction (1 vs. 0.78 ng/mL p < 0.05). The diagnostic accuracy of procalcitonin increased significantly when the procalcitonin threshold was adapted to renal function. Conclusions: Procalcitonin is an accurate marker of postoperative infection in cardiac surgery, even in the presence of renal dysfunction. Renal function is an important determinant of procalcitonin levels and, therefore, its diagnostic thresholds must be adapted in the presence of renal dysfunction. J Clin Med. 2022 Dec 7;11(24):7274. 2077-0383 http://hdl.handle.net/20.500.12105/16612 36555891 10.3390/jcm11247274 2077-0383 Journal of clinical medicine Procalcitonin Marker Postoperative infection Renal dysfunction Influence of Renal Dysfunction on the Differential Behaviour of Procalcitonin for the Diagnosis of Postoperative Infection in Cardiac Surgery