2026-04-18T23:36:49Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/165772024-09-27T07:57:37Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Alonso-Herranz, Laura
author
Albarrán-Juárez, Julián
author
Bentzon, Jacob Fog
funder
Novo Nordisk Foundation
funder
Ministerio de Ciencia e Innovación (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
2023-10-17T10:16:20Z
2023-10-17T10:16:20Z
2023
Front Cardiovasc Med. 2023 Aug 21:10:1254114.
2297-055X
http://hdl.handle.net/20.500.12105/16577
37671141
10.3389/fcvm.2023.1254114
Frontiers in cardiovascular medicine
The fibrous cap is formed by smooth muscle cells that accumulate beneath the plaque endothelium. Cap rupture is the main cause of coronary thrombosis, leading to infarction and sudden cardiac death. Therefore, the qualities of the cap are primary determinants of the clinical outcome of coronary and carotid atherosclerosis. In this mini-review, we discuss current knowledge about the formation of the fibrous cap, including cell recruitment, clonal expansion, and central molecular signaling pathways. We also examine the differences between mouse and human fibrous caps and explore the impact of anti-atherosclerotic therapies on the state of the fibrous cap. We propose that the cap should be understood as a neo-media to substitute for the original media that becomes separated from the surface endothelium during atherogenesis and that embryonic pathways involved in the development of the arteria media contribute to cap formation.
eng
Mechanisms of fibrous cap formation in atherosclerosis.
journal article
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URL
https://repisalud.isciii.es/bitstreams/9260ad3e-9c94-4163-a2dc-bbc3160b36a6/download
File
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application/pdf
Mechanisms of fibrous cap_Front Cardiovasc Med_2023.pdf
URL
https://repisalud.isciii.es/bitstreams/c04da853-3e75-4bfb-8869-dc0d7ebe6f89/download
File
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text/plain
Mechanisms of fibrous cap_Front Cardiovasc Med_2023.pdf.txt