2026-04-29T04:09:30Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/165732024-09-27T10:00:49Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Cordero, Alberto
author
Dalmau González-Gallarza, Regina
author
Masana, Lluis
author
Fuster, Valentin
author
Castellano, Jose Mª
author
Ruiz Olivar, José Emilio
author
Zsolt, Ilonka
author
Sicras-Mainar, Antoni
author
González Juanatey, Jose Ramón
funder
Ferrer
2023-10-17T09:27:43Z
2023-10-17T09:27:43Z
2023
Clinicoecon Outcomes Res. 2023 Jul 19:15:559-571.
1178-6981
http://hdl.handle.net/20.500.12105/16573
37489131
10.2147/CEOR.S396290
ClinicoEconomics and outcomes research : CEOR
PURPOSE
The aim of this study was to estimate health-care resources utilization, costs and cost-effectiveness associated with the treatment with CNIC-Polypill as secondary prevention of atherosclerotic cardiovascular disease (ASCVD) compared to other treatments, in clinical practice in Spain.
PATIENTS AND METHODS
An observational, retrospective study was performed using medical records (economic results [healthcare perspective], NEPTUNO-study; BIG-PAC-database) of patients who initiated secondary prevention between 2015 and 2018. Patients were followed up to 2 years (maximum). Four cohorts were balanced with a propensity-score-matching (PSM): 1) CNIC-Polypill (aspirin+atorvastatin+ramipril), 2) Monocomponents (same separate drugs), 3) Equipotent (equipotent drugs) and 4) Other therapies ([OT], other cardiovascular drugs). Incidence of cardiovascular events, health-care resources utilization and healthcare and non-healthcare costs (2020 Euros) were compared. Incremental cost-effectiveness ratios per cardiovascular event avoided were estimated.
RESULTS
After PSM, 1614 patients were recruited in each study cohort. The accumulated incidence of cardiovascular events during the 24-month follow-up was lower in the CNIC-Polypill cohort vs the other cohorts (19.8% vs Monocomponents: 23.3%, Equipotent: 25.5% and OT: 26.8%; p<0.01). During the follow-up period, the CNIC-Polypill cohort also reduced the health-care resources utilization per patient compared to the other cohorts, particularly primary care visits (16.6 vs Monocomponents: 18.7, Equipotent: 18.9 and OT: 21.0; p<0.001) and hospitalization days (2.3 vs Monocomponents: 3.4, Equipotent: 3.7 and OT: 4.0; p<0.001). The treatment cost in the CNIC-Polypill cohort was lower than that in the other cohorts (€4668 vs Monocomponents: €5587; Equipotent: €5682 and OT: €6016; p<0.001) (Difference: -€919, -€1014 and -€1348, respectively). Due to the reduction of cardiovascular events and costs, the CNIC-Polypill is a dominant alternative compared to the other treatments.
CONCLUSION
CNIC-Polypill reduces recurrent major cardiovascular events and costs, being a cost-saving strategy as secondary prevention of ASCVD.
eng
Economic Burden Associated with the Treatment with a Cardiovascular Polypill in Secondary Prevention in Spain: Cost-Effectiveness Results of the NEPTUNO Study.
journal article
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Economic Burden Associated_Clinicoecon Outcomes Res_2023.pdf
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https://repisalud.isciii.es/bitstreams/3303b03d-2d15-463c-a056-7708b40e74b4/download
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Economic Burden Associated_Clinicoecon Outcomes Res_2023.pdf.txt