2026-06-14T03:37:51Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/165662024-09-27T09:59:06Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Rodriguez-Galan, Ana
author
Dosil, Sara G
author
Hrčková, Anna
author
Fernandez-Messina, Lola
author
Feketová, Zuzana
author
Pokorná, Julie
author
Fernandez-Delgado, Irene
author
Camafeita, Emilio
author
Gómez, Manuel José
author
Ramírez-Huesca, Marta
author
Gutierrez-Vazquez, Cristina
author
Sanchez-Cabo, Fatima
author
Vazquez, Jesus
author
Vaňáčová, Štěpánka
author
Sánchez-Madrid, Francisco
funder
Comunidad de Madrid (España)
funder
Fundación La Caixa
funder
Asociación Española Contra el Cáncer
funder
Centro de Investigación Biomédica en Red - CIBERCV (Enfermedades Cardiovasculares)
funder
Ministerio de Ciencia e Innovación (España)
funder
Instituto de Salud Carlos III
funder
Ministerio de Economía y Competitividad (España)
funder
Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)
funder
Ministerio de Universidades (España)
2023-10-16T13:04:16Z
2023-10-16T13:04:16Z
2023-08-30
Cell Mol Life Sci. 2023 Aug 30;80(9):273.
10.1007/s00018-023-04925-2
1420-9071
Cellular and molecular life sciences : CMLS
37646974
http://hdl.handle.net/20.500.12105/16566
ISG20L2, a 3' to 5' exoribonuclease previously associated with ribosome biogenesis, is identified here in activated T cells as an enzyme with a preferential affinity for uridylated miRNA substrates. This enzyme is upregulated in T lymphocytes upon TCR and IFN type I stimulation and appears to be involved in regulating T cell function. ISG20L2 silencing leads to an increased basal expression of CD69 and induces greater IL2 secretion. However, ISG20L2 absence impairs CD25 upregulation, CD3 synaptic accumulation and MTOC translocation towards the antigen-presenting cell during immune synapsis. Remarkably, ISG20L2 controls the expression of immunoregulatory molecules, such as AHR, NKG2D, CTLA-4, CD137, TIM-3, PD-L1 or PD-1, which show increased levels in ISG20L2 knockout T cells. The dysregulation observed in these key molecules for T cell responses support a role for this exonuclease as a novel RNA-based regulator of T cell function.
eng
ISG20L2: an RNA nuclease regulating T cell activation.
journal article
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URL
https://repisalud.isciii.es/bitstreams/ef9e5209-8db0-4661-8e29-1629f6f15b95/download
File
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application/pdf
ISG20L2_Cell Mol Life Sci_2023.pdf
URL
https://repisalud.isciii.es/bitstreams/1ff0826d-2527-4a30-a13b-cf41d3c5d3f4/download
File
MD5
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text/plain
ISG20L2_Cell Mol Life Sci_2023.pdf.txt