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oai:repisalud.isciii.es:20.500.12105/165652024-09-27T07:55:30Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605

00925njm 22002777a 4500 dc Maier, Jeanette A author Andres, Vicente author Castiglioni, Sara author Giudici, Alessandro author Lau, Emily S author Nemcsik, János author Seta, Francesca author Zaninotto, Paola author Catalano, Mariella author Hamburg, Naomi M author 2023-08-25 Vascular aging, i.e., the deterioration of the structure and function of the arteries over the life course, predicts cardiovascular events and mortality. Vascular degeneration can be recognized before becoming clinically symptomatic; therefore, its assessment allows the early identification of individuals at risk. This opens the possibility of minimizing disease progression. To review these issues, a search was completed using PubMed, MEDLINE, and Google Scholar from 2000 to date. As a network of clinicians and scientists involved in vascular medicine, we here describe the structural and functional age-dependent alterations of the arteries, the clinical tools for an early diagnosis of vascular aging, and the cellular and molecular events implicated. It emerges that more studies are necessary to identify the best strategy to quantify vascular aging, and to design proper physical activity programs, nutritional and pharmacological strategies, as well as social interventions to prevent, delay, and eventually revert the disease. J Clin Med. 2023 Aug 25;12(17):5512. 2077-0383 http://hdl.handle.net/20.500.12105/16565 37685580 10.3390/jcm12175512 Journal of clinical medicine Aging and Vascular Disease: A Multidisciplinary Overview.