2026-08-29T09:10:43Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/165512024-11-29T08:12:07Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19609col_20.500.12105_16968
Repisalud
author
Martínez-Baz, Iván
author
Fernández-Huerta, Miguel
author
Navascués, Ana
author
Pozo Sanchez, Francisco
author
Trobajo-Sanmartín, Camino
author
Casado, Itziar
author
Echeverria, Aitziber
author
Ezpeleta, Carmen
author
Castilla Catalán, Jesús
funder
Unión Europea. European Centre for Disease Prevention and Control (ECDC)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Instituto de Salud Carlos III
2023-10-16T09:57:46Z
2023-10-16T09:57:46Z
2023-09-12
Vaccines (Basel). 2023 Sep 12;11(9):1478.
10.3390/vaccines11091478
2076-393X
Vaccines
37766154
http://hdl.handle.net/20.500.12105/16551
We estimated influenza vaccine effectiveness (IVE) in preventing outpatient and hospitalized cases in the 2022-2023 season. A test-negative design included a representative sample of outpatients and all hospitalized patients with influenza-like illness (ILI) from October 2022 to May 2023 in Navarre, Spain. ILI patients were tested by PCR for influenza virus. Influenza vaccination status was compared between confirmed influenza cases and test-negative controls. Among 3321 ILI patients tested, IVE to prevent influenza cases was 34% (95% confidence interval (CI): 16 to 48) overall, 85% (95%CI: 63 to 94) against influenza B, and 28% (95%CI: 3 to 46) against A(H3N2). Among 558 outpatients, 222 (40%) were confirmed for influenza: 55% A(H3N2), 11% A(H1N1), and 31% B. Overall, IVE to prevent outpatient cases was 48% (95%CI: 8 to 70), 88% (95%CI: 3 to 98) against influenza B, and 50% (95%CI: -4 to 76) against A(H3N2). Of 2763 hospitalized patients, 349 (13%) were positive for influenza: 64% A(H3N2), 17% A(H1N1), and 8% B. IVE to prevent hospitalization was 24% (95%CI: -1 to 42) overall, 82% (95%CI: 49 to 93) against influenza B, and 16% (95%CI: -17 to 40) against A(H3N2). No IVE was observed in preventing influenza A(H1N1). IVE was high to prevent influenza B, moderate against A(H3N2) and null against A(H1N1). A lower proportion of influenza B cases may explain the smaller IVE in hospitalized patients than in outpatients. The null IVE against A(H1N1) was consistent with the observed antigenic drift and supports the new composition of the 2023-2024 influenza vaccine.
eng
Case-control study
Influenza
Influenza vaccine
Repeated vaccination
Vaccine effectiveness
Influenza Vaccine Effectiveness in Preventing Laboratory-Confirmed Influenza Cases and Hospitalizations in Navarre, Spain, 2022-2023
research article
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InfluenzaVaccineEffectivenessPreventing_2023.pdf.txt
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