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oai:repisalud.isciii.es:20.500.12105/164932025-04-07T14:48:02Zcom_20.500.12105_2052com_20.500.12105_2051com_20.500.12105_15322col_20.500.12105_19608col_20.500.12105_16963col_20.500.12105_16969col_20.500.12105_16987

00925njm 22002777a 4500 dc Bernardino, Jose Ignacio author Alejos, Belén author Rodriguez-Centeno, Javier author Esteban-Cantos, Andres author Mora-Rojas, Beatriz author Montejano, Rocío author De Miguel, Rosa author Montero-Alonso, Marta author Ayerdi, Oskar author Hernández-Gutierrez, Cristina author Curran, Adriá author Arribas, José R author Rodés, Berta author Cohort of the Spanish HIV/AIDS Research Network (CoRIS) author 2023-07-16 We investigated whether blood telomere length (TL), epigenetic age acceleration (EAA), and soluble inflammatory monocyte cytokines are associated with cardiovascular events or diabetes (DM) in people living with HIV (PLHIV). This was a case-control study nested in the Spanish HIV/AIDS Cohort (CoRIS). Cases with myocardial infarction, stroke, sudden death, or diabetes after starting antiretroviral therapy were included with the available samples and controls matched for sex, age, tobacco use, pre-ART CD4 cell count, viral load, and sample time-point. TL (T/S ratio) was analysed by quantitative PCR and EAA with DNA methylation changes by next-generation sequencing using the Weidner formula. Conditional logistic regression was used to explore the association with cardiometabolic events. In total, 180 participants (94 cases (22 myocardial infarction/sudden death, 12 strokes, and 60 DM) and 94 controls) were included. Of these, 84% were male, median (IQR) age 46 years (40-56), 53% were current smokers, and 22% had CD4 count ≤ 200 cells/mm3 and a median (IQR) log viral load of 4.52 (3.77-5.09). TL and EAA were similar in the cases and controls. There were no significant associations between TL, EAA, and monocyte cytokines with cardiometabolic events. TL and EAA were mildly negatively correlated with sCD14 (rho = -0.23; p = 0.01) and CCL2/MCP-1 (rho = -0.17; p = 0.02). We found no associations between TL, EAA, and monocyte cytokines with cardiovascular events or diabetes. Further studies are needed to elucidate the clinical value of epigenetic biomarkers and TL in PLHIV. Microorganisms. 2023 Jul 16;11(7):1818. 10.3390/microorganisms11071818 2076-2607 Microorganisms 37512990 http://hdl.handle.net/20.500.12105/16493 HIV infection Blood telomere length Epigenetic age acceleration Monocyte activation Cardiovascular disease Diabetes Monocyte Activation and Ageing Biomarkers in the Development of Cardiovascular Ischaemic Events or Diabetes in People with HIV