2026-04-18T13:59:44Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/164532024-09-27T10:01:07Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Sotodosos-Alonso, Laura
author
Pulgarín-Alfaro, Marta
author
del Pozo, Miguel Angel
funder
Ministerio de Ciencia e Innovación (España)
funder
Agencia Estatal de Investigación (España)
funder
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
funder
Comunidad de Madrid (España)
funder
Fundación La Marató TV3
funder
Asociación Española Contra el Cáncer
funder
Fundación La Caixa
2023-09-12T13:12:24Z
2023-09-12T13:12:24Z
2023-03-20
Cells. 2023 Mar 20;12(6):942.
http://hdl.handle.net/20.500.12105/16453
36980283
10.3390/cells12060942
2073-4409
Cells
The plasma membrane (PM) is subjected to multiple mechanical forces, and it must adapt and respond to them. PM invaginations named caveolae, with a specific protein and lipid composition, play a crucial role in this mechanosensing and mechanotransduction process. They respond to PM tension changes by flattening, contributing to the buffering of high-range increases in mechanical tension, while novel structures termed dolines, sharing Caveolin1 as the main component, gradually respond to low and medium forces. Caveolae are associated with different types of cytoskeletal filaments, which regulate membrane tension and also initiate multiple mechanotransduction pathways. Caveolar components sense the mechanical properties of the substrate and orchestrate responses that modify the extracellular matrix (ECM) according to these stimuli. They perform this function through both physical remodeling of ECM, where the actin cytoskeleton is a central player, and via the chemical alteration of the ECM composition by exosome deposition. Here, we review mechanotransduction regulation mediated by caveolae and caveolar components, focusing on how mechanical cues are transmitted through the cellular cytoskeleton and how caveolae respond and remodel the ECM.
eng
Caveolae Mechanotransduction at the Interface between Cytoskeleton and Extracellular Matrix.
review
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URL
https://repisalud.isciii.es/bitstreams/ddc951f6-7cfc-4e33-8ab3-289896984e41/download
File
MD5
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application/pdf
Caveolae Mechanotransduction_Cells_2023.pdf
URL
https://repisalud.isciii.es/bitstreams/b7559626-cb00-4d53-a421-6eed33864f11/download
File
MD5
c49b8ea9cc6f70bdd2b1618fcf6d8cec
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text/plain
Caveolae Mechanotransduction_Cells_2023.pdf.txt