2026-04-20T09:12:44Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/164502024-09-27T08:08:19Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
López-Méndez, Tania B
author
Sánchez-Álvarez, Miguel
author
Trionfetti, Flavia
author
Pedraz, José L
author
Tripodi, Marco
author
Cordani, Marco
author
Strippoli, Raffaele
author
González-Valdivieso, Juan
funder
Ministerio de Ciencia e Innovación (España)
funder
Ministerio de Universidades (España)
2023-09-12T11:27:35Z
2023-09-12T11:27:35Z
2023-03-04
Cell Biosci. 2023 Mar 4;13(1):44.
2045-3701
http://hdl.handle.net/20.500.12105/16450
36871010
10.1186/s13578-023-00986-9
Cell & bioscience
In recent years, progress in nanotechnology provided new tools to treat cancer more effectively. Advances in biomaterials tailored for drug delivery have the potential to overcome the limited selectivity and side effects frequently associated with traditional therapeutic agents. While autophagy is pivotal in determining cell fate and adaptation to different challenges, and despite the fact that it is frequently dysregulated in cancer, antitumor therapeutic strategies leveraging on or targeting this process are scarce. This is due to many reasons, including the very contextual effects of autophagy in cancer, low bioavailability and non-targeted delivery of existing autophagy modulatory compounds. Conjugating the versatile characteristics of nanoparticles with autophagy modulators may render these drugs safer and more effective for cancer treatment. Here, we review current standing questions on the biology of autophagy in tumor progression, and precursory studies and the state-of-the-art in harnessing nanomaterials science to enhance the specificity and therapeutic potential of autophagy modulators.
eng
Nanomedicine for autophagy modulation in cancer therapy: a clinical perspective.
review
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URL
https://repisalud.isciii.es/bitstreams/7518a9f9-2d89-48f4-b93a-f975027c5571/download
File
MD5
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application/pdf
Nanomedicine for autophagy_Cell Biosci_2023.pdf
URL
https://repisalud.isciii.es/bitstreams/9f7216a1-7f5d-4d76-a2c7-9effcf761204/download
File
MD5
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text/plain
Nanomedicine for autophagy_Cell Biosci_2023.pdf.txt