2026-06-14T03:37:42Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/164482024-09-27T08:55:09Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
McEwan, Phil
author
Harrison, Cale
author
Binnie, Rhona
author
Lewis, Ruth D
author
Cohen-Solal, Alain
author
Lund, Lars H
author
Ohlsson, Marcus
author
von Haehling, Stephan
author
Comin-Colet, Josep
author
Pascual-Figal, Domingo A
author
Wächter, Sandra
author
Dorigotti, Fabio
author
de Arellano, Antonio Ramirez
author
Ponikowski, Piotr
author
Jankowska, Ewa A
funder
CSL Vifor
2023-09-12T11:03:41Z
2023-09-12T11:03:41Z
2023-03
Eur J Heart Fail. 2023 Mar;25(3):389-398.
10.1002/ejhf.2788
1879-0844
European journal of heart failure
36718652
http://hdl.handle.net/20.500.12105/16448
AIMS
Iron deficiency (ID) is comorbid in up to 50% patients with heart failure (HF) and exacerbates disease burden. Ferric carboxymaltose (FCM) reduced HF hospitalizations and improved quality of life when used to treat ID at discharge in patients hospitalized for acute HF with left ventricular ejection fraction <50% in the AFFIRM-AHF trial. We quantified the effect of FCM on burden of disease and the wider pharmacoeconomic implications in France, Germany, Poland, Spain and Sweden.
METHODS AND RESULTS
The per country eligible population was calculated, aligning with the 2021 European Society of Cardiology (ESC) HF guidelines and the AFFIRM-AHF trial. Changes in burden of disease with FCM versus standard of care (SoC) were represented by disability-adjusted life years (DALYs), hospitalization episodes and bed days, using AFFIRM-AHF data. A Markov model was adapted to each country to estimate cost-effectiveness and combined with epidemiology data to calculate the impact on healthcare budgets. Between 335 (Sweden) and 13 237 (Germany) DALYs were predicted to be avoided with FCM use annually. Fewer hospitalizations and shorter lengths of stay associated with FCM compared to SoC were projected to result in substantial annual savings in bed days, from 5215 in Sweden to 205 630 in Germany. In all countries, FCM was predicted to be dominant (cost saving with gains in quality-adjusted life years), resulting in net savings to healthcare budgets within 1 year.
CONCLUSIONS
This comprehensive evaluation of FCM therapy highlights the potential benefits that could be realized through implementation of the ESC HF guideline recommendations regarding ID treatment.
eng
Impact of ferric carboxymaltose for iron deficiency at discharge after heart failure hospitalization: a European multinational economic evaluation.
journal article
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Impact of ferric carboxymaltose_Eur J Heart Fail_2023.pdf
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Impact of ferric carboxymaltose_Eur J Heart Fail_2023.pdf.txt