2026-04-23T15:33:16Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/164412024-09-27T09:08:49Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Palomino-Segura, Miguel
author
Sicilia, Jon
author
Ballesteros, Iván
author
Hidalgo, Andres
funder
Ministerio de Ciencia e Innovación (España)
funder
Fundación La Caixa
funder
Fondation Leducq
funder
Fundación ProCNIC
funder
Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)
2023-09-11T13:47:29Z
2023-09-11T13:47:29Z
2023-04
Nat Immunol. 2023 Apr;24(4):575-584.
http://hdl.handle.net/20.500.12105/16441
36959290
10.1038/s41590-023-01452-x
1529-2916
Nature immunology
Neutrophils are formidable defenders. Their vast numbers, constant production, high cytotoxicity and capacity to produce extracellular traps, underlie their ability to efficiently protect in a microorganism-rich world. However, neutrophils are much more than immune sentinels, as evidenced by the expanding repertoire of functions discovered in the context of tissue homeostasis, regeneration or chronic pathologies. In this Perspective, we discuss general functional features of the neutrophil compartment that may be relevant in most, if not all, physiological scenarios in which they participate, including specialization in naïve tissues, transcriptional noise in the bloodstream as a potential strategy for diversification and functional bias in inflammatory sites. We intentionally present the reader with more questions than answers and propose models and approaches that we hope will shed new light onto the biology of these fascinating cells and spark new directions of research.
eng
Strategies of neutrophil diversification.
journal article
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Strategies of neutrophil diversification_Nat Immunol_2023.pdf
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Strategies of neutrophil diversification_Nat Immunol_2023.pdf.txt