2026-05-30T08:26:27Zhttps://repisalud.isciii.es/rest/oai/requestoai:repisalud.isciii.es:20.500.12105/164402024-09-21T12:31:50Zcom_20.500.12105_19604com_20.500.12105_2051col_20.500.12105_19605
Repisalud
author
Safi, Rémi
author
Sánchez-Álvarez, Miguel
author
Bosch, Marta
author
Demangel, Caroline
author
Parton, Robert G
author
Pol, Albert
funder
Unión Europea. Comisión Europea. H2020
funder
Australian Research Council
funder
Unión Europea. Comisión Europea. European Research Council (ERC)
funder
Instituto de Salud Carlos III
funder
Lady Tata Memorial Trust
funder
Marie Curie
funder
Ministerio de Ciencia e Innovación (España)
funder
Fundación ProCNIC
funder
Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España)
2023-09-11T11:21:04Z
2023-09-11T11:21:04Z
2023-08
Immunol Rev. 2023 Aug;317(1):113-136.
10.1111/imr.13199
1600-065X
Immunological reviews
36960679
http://hdl.handle.net/20.500.12105/16440
Microbes have developed many strategies to subvert host organisms, which, in turn, evolved several innate immune responses. As major lipid storage organelles of eukaryotes, lipid droplets (LDs) are an attractive source of nutrients for invaders. Intracellular viruses, bacteria, and protozoan parasites induce and physically interact with LDs, and the current view is that they "hijack" LDs to draw on substrates for host colonization. This dogma has been challenged by the recent demonstration that LDs are endowed with a protein-mediated antibiotic activity, which is upregulated in response to danger signals and sepsis. Dependence on host nutrients could be a generic "Achilles' heel" of intracellular pathogens and LDs a suitable chokepoint harnessed by innate immunity to organize a front-line defense. Here, we will provide a brief overview of the state of the conflict and discuss potential mechanisms driving the formation of the 'defensive-LDs' functioning as hubs of innate immunity.
eng
Defensive-lipid droplets: Cellular organelles designed for antimicrobial immunity.
review
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URL
https://repisalud.isciii.es/bitstreams/24d08a98-4ec7-4ca8-b8d8-e26c7034c5c7/download
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Defensive_lipid droplets_Immunol Rev_2023.pdf
URL
https://repisalud.isciii.es/bitstreams/0aa7ae54-411e-48ef-b481-0e9aa5c9f83a/download
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text/plain
Defensive_lipid droplets_Immunol Rev_2023.pdf.txt